BMPRIA | definition of BMPRIA by Medical dictionary
BMPRIA A gene on chromosome 10q22.3 that encodes a member of the type-I bone morphogenetic protein (BMP)-receptor family of transmembrane serine/threonine kinases, which binds BMPs and plays a central role in endochondral bone formation and embryogenesis. Type-I receptors require their respective type-II receptors for ligand binding. Type-II receptors phosphorylate and activate type-I receptors, which autophosphorylate then bind and activate SMAD transcriptional regulators.
BMPRIA mutations are associated with primary pulmonary hypertension and brachydactyly type 2A.
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References in periodicals archive
Mochida et al., "Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA
) in osteoblasts," Journal ofBone and Mineral Research, vol.
BMP Receptor (BMPRIa
and BMPRII) Expression Levels Were Upregulated with Hypoxia and I/R.
Mapping of hereditary mixed polyposis syndrome (HMPS) to chromosome 10q23 by genomewide high density single nucleotide polymorphism (SNP) SCAN and identification of BMPRIA
loss of function.
BMP4 and BMP type I receptor (BMPRIA
) are overexpressed in coronal phase of a rat molar.