GDF.ac.2

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GDF.ac.2

A gene on chromosome 10q11.22 that encodes a member of the bone morphogenetic protein (BMP) family, which regulates cell growth and differentiation in both embryonic and adult tissues. GDF2 it thought to play a role in the adult liver and in differentiation of cholinergic central nervous system neurones.

References in periodicals archive ?

Binding of the BMP9 and 10 results in intracellular signaling via the phosphorylation of SMAD1, 5, and 8.

Transforming of the Tumor Microenvironment: Implications for TGF-[beta] Inhibition in the Context of Immune-Checkpoint Therapy

Chen et al., "MIR-21 synergizes with BMP9 in osteogenic differentiationby activating the BMP9/Smad signaling pathway in murine multilineage cells," International Journal of Molecular Medicine, vol.

MicroRNA Mediating Networks in Granulosa Cells Associated with Ovarian Follicular Development

BMP9 and COX-2 form an important regulatory loop in BMP9-induced osteogenic differentiation of mesenchymal stem cells.

Role of Epithelium Sodium Channel in Bone Formation

The list includes NPPS (nucleotide pyrophosphatase)/ENNP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1), (10) TGFB1 (transforming growth factor [beta]1), (23) ESR (estrogen receptor), (24) IL-1[beta], (24) VDR (vitamin D receptor), (25) BMP2, (26) RUNX2, (27) IL-15RA, (28) BMP9, (29) and TGFB3.

(2012) Association of a BMP9 haplotype with ossification of the posterior longitudinal ligament (OPLL) in a Chinese population.

Genomic study of ossification of the posterior longitudinal ligament of the spine

Identification and quantification of BMP4, BMP6 and BMP9 in bovine and human serum.

Bone morphogenetic protein levels in osteoarthritis/ Osteoartritte kemik morfogenik protein duzeyleri

BMP9 has also been shown to be involved in a small number of cases.

Hereditary haemorrhagic telangiectasia in North African and sub-Saharan patients

BMPER, which is expressed by endothelial cells, directly binds to various BMPs including BMP4 and BMP9 and inhibits their signaling [48, 49].

Impaired resolution of inflammation in the Endoglin heterozygous mouse model of chronic colitis

BMP9 induces both ID1 and ID3 which are necessary for induction of Ephrin B2 [69].

Contribution of Inhibitor of DNA Binding/Differentiation-3 and Endocrine Disrupting Chemicals to Pathophysiological Aspects of Chronic Disease

Wang et al., "The role of COX-2 in mediating the effect of PTEN on BMP9 induced osteogenic differentiation in mouse embryonic fibroblasts," Biomaterials, vol.

An Overview of Long Noncoding RNAs Involved in Bone Regeneration from Mesenchymal Stem Cells

Zu, "Intranasal BMP9 ameliorates alzheimer disease-like pathology and cognitive deficits in APP/PS1 transgenic mice," Frontiers in Molecular Neuroscience, vol.

Icariin Attenuates Synaptic and Cognitive Deficits in an A[[beta].sub.1-42]-Induced Rat Model of Alzheimer's Disease

Neural progenitors that are generated in this way and treated transiently with bone morphogenic protein 9 (BMP9) showed a significant increase in the expression of BFCN markers such as choline acetyltransferase (ChAT), acetylcholinesterase (AChE), and nerve growth factor receptors (NGFR): TrkA and neurotrophin p75.

Generation of Cholinergic and Dopaminergic Interneurons from Human Pluripotent Stem Cells as a Relevant Tool for In Vitro Modeling of Neurological Disorders Pathology and Therapy