BMP8B

BMP8B

A gene on chromosome 1p35-p32 that encodes bone morphogenetic protein-8b, which may play a role in early development and bone induction.
References in periodicals archive ?
Martins et al., "BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions," Cell, vol.
La activacion de la cascada de senalizacion a traves de BMP4 producida en el ectodermo extraembrionario, es necesario para la generacion de celulas germinales primordiales, mientras que otros BMPs tales como BMP8b (producido por el ectodermo extraembrionario) y BMP2 (producido por el endodermo visceral), han demostrado su importancia en el establecimiento del numero normal de estas celulas.
Factors such as BMP7 [84, 85], BMP8b [86], FGF21 [87, 88], prostaglandins [89, 90], natriuretic peptides [91], and [beta]-aminoisobutyric acid (BAIBA) [53] can influence the differentiation of beige adipocytes.
Gene ontology: biological Genes p-Value process terms Cell cycle CCNB1, CCNB2, MNAT1, CDC2, 2.7 E-14 CDKN 1 A, CDKN3, CDKN2A, ANAPC1, CDK10 Cellular metabolism KRT15, KIF1B, ZNF697, 4.3E-13 PRG2, P2RY2,IMMP2L Growth factor and growth BMP-2, TCF[beta]1, VEGF, 1.2E-11 factor receptor activity BMP8B, CSF1, FCFR1, BMPR2, 1GF2R, PDCFB, TGFBR2, NRP1, CCR2 Biosynthetic process CEL, COL11A2, ACPP, MMP14, 1.8E-9 CACNB1, ALPL, CDH1, ITGA3, SERPINB10, TAF4B, ABCB10, IRF8 Cell proliferation ATF3, MK167, S100A6, FTH1, DHCR7 2.1E-8 Signal transduction MAP2K3, MAPK14, MAP3K10, BAMBI, NDRG2, ECM1, SMAD7 5.5E-7 Apoptosis MYC, P53AIP1, ZBTB16, BBC3, 1.3E-5 VHL, CASP3, APITD1 Table 5 KEGG pathway analysis.
The research, led by scientists at the University of Cambridge Metabolic Research Laboratories at the Institute of Metabolic Science, discovered that the protein BMP8B acts on a specific metabolic system (which operates in the brain and the tissues) to regulate brown fat, making it a potential therapeutic target.
However, BMP8B seems to be very specific for regulating the heat producing activity of brown fat, making it a more ideal mechanism for new therapies."
The experiments showed that when mice lacked the protein BMP8B they found it more difficult to maintain their normal body temperature.
The research, which was conducted in mice and led by scientists at the University of Cambridge Metabolic Research Laboratories at the Institute of Metabolic Science, discovered that the protein BMP8B acts on a specific metabolic system (which operates in the brain and the tissues) to regulate brown fat, making it a potential therapeutic target.
However, BMP8B seems to be very specific for regulating the heat producing activity of brown fat, making it a more ideal mechanism for new therapies," said Dr Andrew Whittle, one of the authors of the paper from the Institute of Metabolic Science.
Additionally, when the researchers treated brown fat cells with BMP8B they responded more strongly to activation by the nervous system.