BMP15

BMP15

A gene on chromosome Xp11.2 that encodes bone morphogenetic protein 15, which is thought to play a role in oocyte and follicular development.
References in periodicals archive ?
Genotyping of BMPR1B, BMP15 and GDF9 genes in Chilean sheep breeds and association with prolificacy.
Many genes contributing to reproduction have been identified in sheep, including BMP15 (Wang et al.
Missense mutations in the BMP15 gene are associated with ovarian failure.
Until now, the association of BMP15 exon 2 genetic variations with ovulation rate and litter size has been reported in some sheep breeds but not in the Arabic sheep.
Algunos genes que coordinan el desarrollo de la celula germinal a un estadio primordial, como GDF9, BMP15 y NGF.
BMP1 - 8p21; BMP2 - 20p12; BMP3 - 14p22; BMP4 - 14q22-q23; BMP5 - 6p12,1; BMP6 - 6p12,1; BMP7 - 20q13; BMP8a - 1p35p32; BMP8b - 1p35-p32; BMP10 - 2p14; BMP15 - Xp11,2.
In a family affected by hypergonadotropic ovarian failure, a mutation in the pro-region of the BMP15 gene (Y235C) was found in 2 affected sisters (1), and 3 linked markers within the BMP15 gene (-673C>T, -9C>G and IVS1 + 905A>G) are associated with high follicle production in women undergoing recombinant FSH stimulation (2).
Hanrahan JP, Gregan SM, Mulsant P, Mullen M, Davis GH, Powell R, Galloway SM (2004) Mutations in the genes for oocitederived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis Aries).
Growth factors GDF9 and BMP15 play a fundamental role in ovarian functioning and are essential for oocyte maturation processes, ovulation, fertilization and luteinization in mammals.