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A gene on chromosome 20q11.2 that encodes a member of the bone morphogenetic protein (BMP) family, which regulates cell growth and differentiation in both embryonic and adult bone and cartilage.

Molecular pathology
GDF5 mutations are associated acromesomelic dysplasia, Hunter-Thompson type, brachydactyly, type C, and chondrodysplasia, Grebe type.
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References in periodicals archive ?
Growth differentiation factor 5 (GDF5), which is also known as cartilage-derived morphogenetic protein 1 (CDMP1) or bone morphogenetic protein 14 (BMP14), belongs to the TGF-[beta] superfamily [24, 25].
BMP14 or CDMP1) has been shown to be a key factor to push primary hMSCs towards an intervertebral-disc-like phenotype [18,19], but it was also confirmed as a stimulating and a strong regenerative factor for disc cells in vitro [20] and in vivo in a rabbit IVD annulus stab degeneration model [21].