BMI1

BMI1

A gene on chromosome 10p11.23, which encodes one of the proteins that participate in the Polycomb group (PcG) multiprotein PRC1-like complex, a complex group of proteins needed to maintain an array of genes (e.g., Hox genes) in a state of transcriptional repression during development. The PcG PRC1 complex acts via chromatin remodelling and histone modification.
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References in periodicals archive ?
These include the ability to reduce intratumor BMI1 associated with elimination of the stem cell-like phenotypes, and the lack of any detectable toxicity.
Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication.
As a member of PRC1, B-lymphoma Mo-MLV insertion region 1 (BMI1) has been reported to be overexpressed in advanced stages and related to poor prognosis in many cancers (19).
This project focuses specifically on understanding the role of BMI1, a stem cell protein that promotes tumor growth when present in high levels within the cell.
[61] In addition to regulating various cellular processes, miRNAs are epigenetic modulators by targeting mRNAs of epigenetic regulators including DNA methyltransferase 3 alpha (DNMT3A), DNA methyltransferase 3 Beta (DNMT3B), polycomb mRNAs, EZH2 (as shown above), BMI1 and HDAC4.
Relative quantification of the mRNA level of Bmi1 was determined using the 2−??Ct method.[23] Each experiment was repeated for three times in duplicates.[8]
Qi et al., "Bmi1 regulates the proliferation of cochlear supporting cells via the canonical Wnt signaling pathway," Molecular Neurobiology, vol.
Wang et al., "Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition," Nature Cell Biology, vol.
They also demonstrated that tumors from Villin-Lin28b/let-7IEC-KO mice exhibited a significant upregulation of stem cell markers including Bmi1, Lrig1, Olfm4, ASCL2, Prom1, LGR5, Msi1, and SOX9, suggesting an expansion of CRC and +4 stem cell-like compartments.
Bmi1 was identified as a barrier to reprogramming by modifying histone marks at key cardiogenic loci, thus inhibiting iCM induction.
Bcl2, Ccnd1, Cdk6, and Sox4), intestinal stem cells (Lgr5, Olfm4, and Bmi1) [10], mucin biology (Muc2 and Muc6), and tight junctions (occludin, zonulin-1, and Jam) was analyzed using real-time PCR (Table S1).