BMI1

BMI1

A gene on chromosome 10p11.23, which encodes one of the proteins that participate in the Polycomb group (PcG) multiprotein PRC1-like complex, a complex group of proteins needed to maintain an array of genes (e.g., Hox genes) in a state of transcriptional repression during development. The PcG PRC1 complex acts via chromatin remodelling and histone modification.
References in periodicals archive ?
2013) RUNX1/AML1 mutant collaborates with BMI1 overexpression in the development of human and murine myelodysplastic syndromes.
One such pathway that has been identified in epithelial cancers, including ovarian, is the BMI1 pathway, which is associated with pluripotent potential of a cell.
July 19, 2013 -- Stemcell researchers here have found a key role for a protein called BMI1 that may help scientists direct the development of tissues to replace damaged organs in the human body.
Washington, July 21 ( ANI ): Researchers have found a key role for a protein called BMI1, which may help scientists develop tissues to replace damaged organs in the human body.
One such example arises in the case of tumor cells expressing the BMI1 polycomb ring finger oncogene (BMI1), an important regulator of normal stem cell self-renewal.
A gene called BMI1 is important for basal stem cells' self-renewal and may also play a role in malignancy.
Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: Relation to adverse epigenetic alteration and poor prognostic scoring.
4th Generation IntelA Core processor s new instructions include IntelA Advanced Vector Extensions 2, gather, BMI1, BMI2, and FMA3 support.
In addition, expression of self-renewal genes (TP63, ABCG2, BMI1, SHH, OCT-4, and NOTCH-1) was inhibited during arsenite exposure but subsequently returned, coincident with progressive inhibition of the PTEN tumor suppressor gene.