ARNTL

(redirected from BMAL1)
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ARNTL

A gene on chromosome 11q15 that encodes a basic helix-loop-helix protein which forms a heterodimer with CLOCK and binds an E-box upstream of PER1, activating it and possibly other circadian-rhythm-associated genes.
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Furthermore, eliminating BMAL1 from their muscles caused a severe disruption in normal sleep patterns, leading to a heightened need for sleep, deeper sleep and a diminished ability to recover.
Alem disso, esses camundongos apresentam testiculos com tamanho menor do que os testiculos dos animais BMAL1 selvagens (wild type: WT), ou seja, aqueles que nao apresentam defeito na expressao de BMAL1 em seus tecidos, alem de apresentarem um reduzido numero de espermatozoide e alteracoes no comportamento sexual (Alvarez e colaboradores, 2008).
2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Schibler and colleagues report similar results in the same issue of Cell, demonstrating that SIRT1 levels rise and fall throughout the day, and that SIRT1, CLOCK and BMAL1 interact in a circadian manner.
The result indicated that that mice with higher levels of BMAL1 in their muscles recovered from sleep deprivation more quickly and in addition, removing BMAL1 from the muscle severely disrupted normal sleep, leading to an increased need for sleep, deeper sleep and a reduced ability to recover.
BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis.
Brain, muscle ARNT-like protein 1 (Bmall) siRNA and Mr or Bmall expression plasmids were used to analyze the effect of BMAL1 on PPAR-a expression in c7 cells.
In the new study, Sassone-Corsi's group shows that SIRT1 indeed acts as tick to CLOCK's tock, removing an acetyl group from histones and also from CLOCK's partner, BMAL1.
acute exposure) increases BMAL1 expression in these cells (Ando et al.
Scientists knew that two genes, BMAL1 and CLOCK, worked together at the core of the clock's molecular machinery to activate the network of circadian genes.
Some of the genes known to be involved in these loops include CLOCK, BMAL1, and PER1 and PER2.