LTB4 is an extremely pro-inflammatory lipid mediator that can exert its activity by binding to receptors BLT1 or BLT2
12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2
(66) 12-HHT was recently found to act on leukotriene [B.sub.4] type-2 receptor (BLT2) (69) and then to promote epidermal wound healing by accelerating keratinocyte migration.
It is also important to remember that 12-HHT is also produced by the TXS reaction as well as [TXA.sub.2], (66) and 12-HHT has the ability to promote epidermal wound healing by accelerating keratinocyte migration via BLT2. (69,70) TXS KO mice exhibited impaired re-epithelialization and delayed wound closure after skin punching.
The LTs exert their actions through interaction with specific 7-transmembrane G-protein-coupled cell surface receptors, BLT1 and BLT2
, representing the high and low-affinity receptor for LTB4, respectively, and CysLT1 receptor (CysLT1R) and CysLT2 receptor (CysLT2R) activated by the CysLTs [6, 7] plus a recently discovered LTE4-specific receptor known as CysLTER that was identified in [CysLT.sub.1]R/[CysLT.sub.2]R double-deficient mice .
And another in vitro experiment indicated that Nox1 lies downstream of BLT2
and mediates UVB-induced ROS production and apoptosis of HaCaT .
The school's performing troupes - including Broadway Ladies, Broadway Bound, Broadway Light, BLT2
and Lite Brites - will perform songs exploring Broadway's rich musical history.
First it meant "Man of Luthany," that is "friend," Luthany being "friendship," the Elvish name of England (BLT2
His guides include the Bums, Legs and Tums Workout, the more gently named BLT2
, Cardio Funk - The Original and the plain Health and Fitness with Derrick Evans.
In fact, the whole race of Dwarves in this text "love[s] gold and silver more dearly than aught else on Earth" and, spurred to ambush and murder by their greed, "have been severed in feud for ever since those days with the Elves, and drawn more nigh in friendship to the kin of Melko" (BLT2