Sequeira et al., "Dermal Blimp1
acts downstream of epidermal TGF(3 and Wnt/(3-catenin to regulate hair follicle formation and growth," Journal of Investigative Dermatology, vol.
Let-7c downregulates B lymphocyte-induced maturation protein-1 (Blimp1
) as well as suppressor of cytokine signaling-1 (SOCS1) expression in dendritic cells, contributing to the extensive production if SLE-relevant proinflammatory cytokines .
PGC specification in humans occurs at ~2 weeks after fertilization when BMP signals target to the mesendoderm of the preprimitive streak embryo, which leads to the induction of SOX17 which, with BLIMP1
, suppresses endodermal differentiation and activates PGC differentiation .
These results also agree with the reduction of Blimp1
expression, a gene related to germ cell identity that downregulates in hypoxia-induced reprogramming (not shown).
They share a surface [IgM.sup.+] CD138hi CD44hi [CD69.sup.+] [TACI.sup.+] C [XCR4.sup.+] CD1dint TIM-1int [MHC-II.sup.+] [CD80.sup.+] [CD86.sup.+] phenotype and express the transcription factors Blimp1
(B-lymphocyteinduced maturation protein1) tambien conocido como Prdm1, funciona mediante la formacion de un complejo con Prmt5 (arginine metiltransferase).
One way in which IRF4 acts is as a transcription factor for BLIMP1
, also a transcription factor itself which plays a key role in plasma cell differentiation.
Calame, "B-1 B lymphocytes require Blimp1
for immunoglobulin secretion," The Journal of Experimental Medicine, vol.
The major stem cell population of hair follicle includes interfollicular label retaining cells (LRCs), double positive HSCs (CD34+/[alpha]6-integrin+), Mts24+ cells, Blimp1
, Nestin, Lgr5+, and Lgr6+ cells (reviewed in ).