PRDM1

(redirected from BLIMP1)

PRDM1

A gene on chromosome 6q21 that encodes a protein which represses beta-interferon gene expression, by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. PRDM1 transcription increases in response to viral induction.
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Sequeira et al., "Dermal Blimp1 acts downstream of epidermal TGF(3 and Wnt/(3-catenin to regulate hair follicle formation and growth," Journal of Investigative Dermatology, vol.
Let-7c downregulates B lymphocyte-induced maturation protein-1 (Blimp1) as well as suppressor of cytokine signaling-1 (SOCS1) expression in dendritic cells, contributing to the extensive production if SLE-relevant proinflammatory cytokines [139].
PGC specification in humans occurs at ~2 weeks after fertilization when BMP signals target to the mesendoderm of the preprimitive streak embryo, which leads to the induction of SOX17 which, with BLIMP1, suppresses endodermal differentiation and activates PGC differentiation [20].
These results also agree with the reduction of Blimp1 expression, a gene related to germ cell identity that downregulates in hypoxia-induced reprogramming (not shown).
They share a surface [IgM.sup.+] CD138hi CD44hi [CD69.sup.+] [TACI.sup.+] C [XCR4.sup.+] CD1dint TIM-1int [MHC-II.sup.+] [CD80.sup.+] [CD86.sup.+] phenotype and express the transcription factors Blimp1 and IRF4.
Blimp1 (B-lymphocyteinduced maturation protein1) tambien conocido como Prdm1, funciona mediante la formacion de un complejo con Prmt5 (arginine metiltransferase).
One way in which IRF4 acts is as a transcription factor for BLIMP1, also a transcription factor itself which plays a key role in plasma cell differentiation.
The major stem cell population of hair follicle includes interfollicular label retaining cells (LRCs), double positive HSCs (CD34+/[alpha]6-integrin+), Mts24+ cells, Blimp1, Nestin, Lgr5+, and Lgr6+ cells (reviewed in [26]).