PRDM1

(redirected from BLIMP-1)

PRDM1

A gene on chromosome 6q21 that encodes a protein which represses beta-interferon gene expression, by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. PRDM1 transcription increases in response to viral induction.
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The researchers further traced this observation to a gene called Prdm1 encoding the protein BLIMP-1, increased expression of which leads to differentiation and proliferation of plasma cells in B cell immune response (Figure 2).