FABP7

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FABP7

A gene on chromosome 6q22-q23 that encodes a brain fatty acid-binding protein possibly involved in the transport of an as-yet unknown hydrophobic ligand with potential morphogenic activity during CNS development. FABP7 is required for establishing the radial glial fibre system in the developing brain, which is necessary for the migration of immature neurons to establish cortical layers.
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(b, A) Protein levels of TUJ1 and BLBP (brain lipid-binding protein) detected by western blot in EBs differentiated for 10 days in adherent culture (5 + 10d).
(a, A) Protein levels of neural markers PAX6, BLBP, and TUJ1 detected by western blot in 5-day-old EBs derived from wild-type and HIF1[alpha]-deficient ESC.
(a, A) The protein level of PAX6, BLBP, and TUJ1 in control (CTR) and [beta]-catenin-transfected ([beta]CAT) 5-day-old EBs (5d) derived from wild-type and Hif1[alpha]-deficient ESC.
Intriguingly, over-expression of early neural genes SOX2 and NESTIN, the radial glial (RG) gene BLBP and the myogenic transcription factor PAX3 (also known as a neural crest stem cell migration marker) was observed in MMC-AFSCs (Figure 2(b)).
While the increase of the RG marker GFAP has already been described in association with spinal cord injury [38], we sought to analyze the levels of RG marker BLBP in MMC-AFSCs.
Moreover, although samples from more patients would be required to confirm our findings, our results suggested that validation of SOX2, NESTIN, PAX3, and BLBP expression in amniotic fluid could be used as an additional tool to confirm MMC diagnosis.
Heintz, "Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS," Neuron, vol.