BL22


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BL22

A 63-kDa anti-CD22 recombinant immunotoxin, containing truncated Pseudomonas exotoxin and variable domains from an anti-CD22 antibody. It was effective against hairy cell leukaemia in phase-II trials of patients who had relapse less than 4 years after cladribine therapy.
References in periodicals archive ?
A genetically engineered drug known as BL22 has sent a type of cancer called hairy cell leukemia into full remission in 11 of 16 patients, a study shows.
The findings, reported in the July 26 NEW ENGLAND JOURNAL OF MEDICINE, suggest that BL22 may become a treatment for this type of leukemia.
The other three had their cancer recur within 16 months of being treated with BL22 but then were successfully treated again, Kreitman says.