At a meeting earlier this year, Karl-Johan Soderholm of the University of Florida in Gainesville reported tha BIS-GMA
is weakly estrogenic in mice.
Properties of BIS-GMA reinforced resin have been compared to PMMA acrylic resins in Table 4.
Table 4: Comparison of properties of BIS-GMA reinforced resin with PMMA acrylic resin  Reinforced Properties BIS-GMA Acrylic Resin resin Volume shrinkage (%) 2.
But over the past two decades, dentists have tended to fill gum-line and other very visible cavities with tooth-colored composites made from ceramic particles embedded in an organic polymer known as BIS-GMA (for bisphenol-A, glycidyl dimethacrylate).
Most dentists have resisted using the more aesthetically pleasing composites for grinding surfaces--initially because the BIS-GMA materials did not hold up as well to wear.
Manu, Development and evaluation of BIS-GMA
based composite dental restorative material, J.
4) went on to develop a light cured BIS-GMA resin (5).
It can be concluded that Chitra polyurethane based adhesive is effective as an Orthodontic bonding agent and with the advantages of increased strength, hardness, and opacity, may well replace BIS-GMA based composite as the bonding agents of the future.