XIAP

(redirected from BIRC4)

XIAP

A gene on chromosome Xq25 that belongs to the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. XIAP acts by binding to tumour necrosis-factor receptor-associated factors TRAF1 and TRAF2, inhibits apoptosis induced by menadione—a free radical inducer and IL1-beta converting enzyme—and inhibits cell-death proteases caspase-3 and caspase-7.

Molecular pathology
XIAP mutations cause X-linked lymphoproliferative syndrome.
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[84] injected an AAV-CAG vector expressing a known caspase inhibitor, baculoviral IAP repeat-containing protein-4 (BIRC4), into one eye on rat models of glaucoma.
HLH-related genes (including AP3B1, FASLG, PRF1, TNFRSF1A, BIRC4, ITK, RAB27A, UNC13D, CASP10, ITPKC, SH2D1A, CD27, LYST, STX11, FAS, MAGT1 and STXBP2) were detected with high-throughput sequencing.
Molecular identification of an HLH - associated gene mutation (ie, PRF1, UNC13D, STX11, STXBP2, Rab27A, SH2D1A, or BIRC4).