BIONJ

BIONJ

Bisphosphonate-induced osteonecrosis of the jaw. A condition linked to the use of IV and oral nitrogen-containing bisphosphonate drugs, resulting in osteonecrosis of the jaw.

Drugs implicated
Zoledronate, pamidronate or combination thereof, used to treat breast cancer or myeloma. About 5% of those with BIONJ were being treated for osteoporosis.

Risk factors
Tooth extractions (50% of cases), mandibular exostoses, periodontal disease, trauma from ill-fitting dentures, smoking, obesity, use of cytotoxic drugs and glucocorticoids.
References in periodicals archive ?
When the number of the common sites was <100 or less than one fourth of the total number of the sites, the maximum parsimony method was used; otherwise BIONJ method with MCL distance matrix was used.
Trees were built with PhyML (26) by using the general time reversible model, BIONJ for the initial tree, and optimized tree topology and branch lengths.