BIONJ

BIONJ

Bisphosphonate-induced osteonecrosis of the jaw. A condition linked to the use of IV and oral nitrogen-containing bisphosphonate drugs, resulting in osteonecrosis of the jaw.

Drugs implicated
Zoledronate, pamidronate or combination thereof, used to treat breast cancer or myeloma. About 5% of those with BIONJ were being treated for osteoporosis.

Risk factors
Tooth extractions (50% of cases), mandibular exostoses, periodontal disease, trauma from ill-fitting dentures, smoking, obesity, use of cytotoxic drugs and glucocorticoids.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Hart is the founding president and CEO of BioNJ, a network of 400 research-based life sciences companies dedicated to driving the innovation ecosystem in New Jersey to improve and save lives and lower the hurdles of health care advancements for society.
Los arboles iniciales para la busqueda heuristica se obtuvieron automaticamente aplicando los algoritmos de Neighbor-Joining y BIONJ a una matriz de distancias que se estimo utilizando la aproximacion de Similitud Maxima compuesta (MLC), y posteriormente se selecciono la topologia con mayor valor logaritmico de similitud.
We generated the initial trees for the heuristic search automatically by applying neighbor-joining and BioNJ algorithms to a matrix of pairwise distances estimated using the maximum composite likelihood approach, and then selecting the topology with superior log likelihood value.
The tree inference options were set to nearest-neighbor interchange, with an automatically generated (neighbor-joining [NJ] and BioNJ) initial tree.
BIONJ: an improved version of the NJ algorithm based on a simple model of sequence data.
"As a hub of medical innovation, NJ is a prime location to establish research facilities that will provide state-of-the-art resources to entrepreneurs, innovators and start-up companies hoping to enhance their research and discover scientific breakthroughs," said Debbie Hart, founding president and chief executive officer of BioNJ. "We look forward to working with the Thomas O.
Initial tree(s) for the heuristic search were obtained automatically by applying the Neighbor-Join and BioNJ algorithms to a matrix of pairwise distances estimated using the Maximum Composite Likelihood (MCL) approach, and then selecting the topology with the higher log likelihood value.
Initial tree for the heuristic search was obtained automatically by applying neighbor-joining and BioNJ algorithms to a matrix of pairwise distances estimated using the maximum composite likelihood (MCL) approach and then selecting the topology with the superior log likelihood value.
Earlier in 2017, O'Connor was also appointed as vice chairman of the board of trustees of BioNJ as well as to the New Jersey Biotechnology Task Force by Governor Chris Christie.
Initial tree(s) for the heuristic search were obtained automatically by applying Neighbor-Join and BioNJ algorithms to a matrix of pairwise distances estimated using the Maximum Composite Likelihood (MCL) approach and then selecting the topology with superior log likelihood value.
He is a member of NewYorkBIO, the New Jersey Technology Council and BioNJ.