KDM1A

(redirected from BHC110)

KDM1A

A gene on chromosome 1p36.12 that encodes a demethylase which acts on histone H3 as a coactivator or a co-repressor, depending on the context.
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All the members share a common core composed of HDAC linked to another protein called BHC110. A variety of other proteins are attached to this core unit, including one involved in X-linked mental retardation and another associated with breast cancer.
He speculates that histone demethylation may actually be the role played by BHC110. If this is indeed the case, "BHC110 is going to be a hot protein," says Shiekhattar.