Parkinsonism, early onset with mental retardation

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Parkinsonism, early onset with mental retardation

An extremely rare (one cohort documented in the world literature) condition (OMIM:311510) characterised by early-onset parkinsonism (postural changes, tremor, rigidity), defects of the basal ganglia, megalencephaly, mental retardation and other variably present signs such as frontal bossing, persistent frontal lobe reflexes, strabismus and seizures.

Molecular pathology
Defects of WSN cause Waisman syndrome.
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