FGF2

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FGF2

A gene on chromosome 4q26 that encodes fibroblast growth factor 2 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration. FGF2 plays a key role in various processes, including limb and nervous system development, wound healing and tumour growth, as well as angiogenesis. It is expressed in normal ovarian tissue and in hepatocellular carcinoma, but not in normal liver cells. FGF2 interacts with FGF receptors FGFR1, -2, -3 and -4.
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Those research studies differentiated BMSCs to oligodendrocytes using some inducers including bFGF, PDGF and T3.
According to the classic report,[14],[15] the fibroblasts could be induced by ADSCs cultured in the 20 ng/ml bFGF and 20 ng/ml EGF medium.
FGF-2 or bFGF mediates the formation of new blood vessels that are critical in the wound-healing process following surgery.
Kim et al., "Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF," Wound Repair and Regeneration, vol.
The use of certain growth factors such as basic fibroblast growth factor (bFGF) [45] can also be employed during surgery to enhance tissue integration.
In the present study, we measured the messenger RNA (mRNA) and protein levels of VEGF, bFGF, and PEDF in the iris tissue of patients who had NVG associated with retinal diseases and had undergone surgical treatment.
Effects of local delivery of bFGF from PLGA microspheres on osseointegration around implants in diabetic rats.
In a study published in STEM CELLS Translational Medicine, they demonstrate how mesenchymal stem cells (MSCs) engineered to over-express basic fibroblast growth factor (bFGF) accelerated the healing of fractures in mice.
Regarding astrogenesis, when treated with basic fibroblast growth factor (bFGF) and IL-6 family cytokine CNTF, cultured rat lgNSCs produced more astrocytes compared with lgNSCs treated only with CNTF, although bFGF alone cannot induce astrogenesis.
In samples from patients in the arthralgic convalescent phase, we noted increases in IL-1[beta], IL-4, IL-6, IL-8, IL-9, IL-13, IL-15, GM-CSF, interferon-[gamma], tumor necrosis factor-[alpha] (TNF-[alpha]), RANTES, basic fibroblast growth factor (bFGF), macrophage inflammatory protein 1[alpha] (MIP1[alpha]), and VEGF in comparison to healthy controls.
The cocktail of bioactive (pro-angiogenic) factors are encapsulated by platelets such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), hepatocyte growth factor (HGF) and insulin-like growth factor (IGF), whereby they contribute to the development of tumour burden.
Los factores que han sido implicados en la regulacion de celulas vasculares incluyen a factores de crecimiento del endotelio vascular (VEGF), factor de crecimiento derivado de plaquetas (PDGF), factor de crecimiento transformador beta-1 (TGF-[beta]1), factor de crecimiento basico de fibroblasto (bFGF), receptores de los factores de crecimiento del endotelio vascular (Fig.1), receptores TIE-1 y TIE-2, angiopoyetinas, factores de coagulacion, entre otros.