BECN1

BECN1

A gene on chromosome 17q21 which encodes Beclin-1, a protein that plays a critical role in regulating autophagy, development, tumourigenesis and neurodegeneration, and is required for the abcission step in cytokinesis. It may play a role in antiviral host defense.
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C] with Beclin (BECN)1 facilitates the localization of BECN1 into lipid rafts and thus allows the activation of phosphatidylinositol 3-kinase (catalytic subunit type-3 or PI3KC3) complex in response to A[[BETA].
Through influence on BECN1 (Beclin 1, autophagy-related) ROS activate formation of class III phosphatidylinositol 3-kinase (PtdIns3K) complexes and positively regulate autophagy; PtdIns3K is an intracellular energy sensor, which specifically responds to the energy depletion [94].
To investigate whether the treatment of 10 uM rapamycin in 24 h-aged IVM oocytes could affect the mRNA expression of autophagy-related genes, the expression of ATG5, BECN1, ATG7, MAP1LC3B, ATG12, GABARAP, and GABARAPL1 was quantified by real-time PCR (Figure 5C).