BDNF


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BDNF

A gene on chromosome 11p13 that encodes brain-derived neurotrophic factor, a nerve growth factor that promotes the survival, migration and differentiation of neuronal precursors in the peripheral and central nervous system, and supports survival of primary sensory neurones originating from the neural crest and ectodermal placodes.
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Blood samples were drawn into chilled tubes containing Na2EDTA (1 mg/ml) and aprotinin (500 U/ml) and were used to determine serum BDNF levels.
The discovery of an estrogen response element- (ERE-) like motif in the BDNF gene promotor region provides a possible mechanism through which estradiol is able to directly regulate BDNF expression [10].
Four different approaches were used to block BDNF-TrkB signaling: immunoneutralization of extracellular BDNF using an anti-BDNF blocking antibody ([alpha]-BDNF), scavenging of extracellular BDNF using a TrkB-Fc Chimera, blockade of TrkB receptor using K252a [46], and inhibition of TrkB dependent Src phosphorylation using PP2.
The corresponding amniotic fluid samples were then withdrawn from our amniotic fluid sample bank, and BDNF was measured in order to compare its levels between normal full-term pregnancies (control group) and the groups of embryos with residual and enhanced growth.
This study was designed to assess, for the first time, the effect of complex sports gestures (acyclic) in a specific sport modality and simple sport gestures (cyclic) on the BDNF blood levels in elite athletes and with respect to sex.
Using mice to model behaviors of depression, the researchers investigated the interaction of BDNF and VEGF.
All the participants received two assessments for BDNF level, N400, and Positive and Negative Syndrome Scale (PANSS) score on the 1st day after enrollment and after the 12-week therapy.
In some clinical trials, it has been shown that in patients with MDD, some growth factors (BDNF, vascular growth factor, insulin-like growth factor-1) change both gene expression and peripheral levels, while antidepressants have a normalizing effect (2, 12-14).
Uno de ellos es el factor neurotropico derivado del cerebro (BDNF, por sus siglas en ingles).