CLEC4C

(redirected from BDCA2)

CLEC4C

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain protein involved in antigen capture, targeting ligands to peptide-loading compartments for presentation to T-cells. CLEC4C may downregulate IFN-alpha/beta expression in plasmacytoid dendritic cells; it may also act as a signalling receptor, activating protein-tyrosine kinases and mobilising intracellular calcium.
References in periodicals archive ?
La expresion de BDCA2 (por la sigla en ingles de blood dendritic cell antigen 2) se uso como control interno para validar la pureza de las celulas, ya que este gen corresponde a un marcador especifico de celulas dendriticas plasmacitoides.
BPDCN characteristically expresses CD4, CD56, CD43, CD45, and PDC-associated antigens such as CD123, TCL-1, BDCA2 (CD303) without expression of T-cell, B-cell, and NK-cell or myelomonocytic lineage specific markers, although expression of CD2 and CD7 is not an uncommon finding.
The diagnosis of BPDCN is largely based on the PDC-associated antigens such as CD123, TCL1, BDCA2, and CLA, but most of these markers have been shown to be expressed by other lesions as well.