CLEC4C

(redirected from BDCA2)

CLEC4C

A gene on chromosome 12p13.2-p12.3 that encodes a C-type lectin domain protein involved in antigen capture, targeting ligands to peptide-loading compartments for presentation to T-cells. CLEC4C may downregulate IFN-alpha/beta expression in plasmacytoid dendritic cells; it may also act as a signalling receptor, activating protein-tyrosine kinases and mobilising intracellular calcium.
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References in periodicals archive ?
These mature pDCs show largely the same immunoprofile as their reactive counterparts, CD123, BDCA2, and TCL1 positive, but occasionally aberrantly express CD2, CD5, CD7, CD10, CD13, CD14, CD15, and CD33.
Though BDCA2 is a specific marker for pDC in immunostaining, it was reported that BDCA2 was an inhibiting signal for TLR9-mediated IFN-[alpha] synthesis in pDCs [60] and BDCA2+ pDC produced a very low amount of IFN-[alpha] in lymph node [61].
The diagnosis is mainly provided by detection of [CD4.sup.+] [CD56.sup.+], [CD123.sup.high], [TCL-1.sup.+], and blood dendritic cell antigen-2 (BDCA2)/[CD303.sup.+] Lin- blasts [3].
They also express CD303 (blood dendritic cell antigen 2, BDCA2), cutaneous lymphocyte-associated antigen (CLA), granzyme B, and TCL1.
BPDCN characteristically expresses CD4, CD56, CD43, CD45, and PDC-associated antigens such as CD123, TCL-1, BDCA2 (CD303) without expression of T-cell, B-cell, and NK-cell or myelomonocytic lineage specific markers, although expression of CD2 and CD7 is not an uncommon finding.
Within the fraction [CD.sup.3-] [CD19.sup.-] [CD56.sup.-], cells expressing CD11c were considered conventional dendritic cells, whereas the BDCA2 expressing cells were classified as plasmacytoid dendritic cells.