BCHE


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BCHE

A gene on chromosome 3q26.1-2 that encodes butyrylcholinesterase, which has a broad substrate spectrum. It contributes to inactivation of the neurotransmitter acetylcholine and can degrade neurotoxic organophosphate esters.
 
Molecular pathology
Mutant alleles at BCHE are responsible for suxamethonium sensitivity.
References in periodicals archive ?
LOD ([micro] Recovery Interbatch Intrabatch Metabolites g/L) (%) (%RSD) (%RSD) AChE -- -- 6.2 12.3 activity BChE activity -- -- 3.1 9.11 6 DAPs 50-125 76.0-112 6.2-14.6 7.1-22.5 3-PBA 1.0 93.0 3.2 3.8 Glyphosate 0.5 80.0 3.0 8.9 AChE: acetylcholinesterase; BChE: butyrylcholinesterase; 6 DAPs are dimethyl phosphate, dimethyl thiophosphate, dimethyl dithiophosphate, diethyl phosphate, diethyl thiophosphate, and diethyl dithiophosphate; 3-PBA: 3-phenoxybenzoic acid.
La butirilcolinesterasa (BChE) tambien llamada pseudocolinesterasa, colinesterasa serica, colinesterasa en plasma y falsa colinesterasa, se sintetiza en el higado y se encuentra en los tejidos exceptuando los eritrocitos (1); no tiene una funcion fisiologica conocida, pero es de importancia toxicologica y farmacologica porque se encarga de hidrolizar esteres exogenos de acidos carboxilicos o de acido fosforico presentes en la succinilcolina, el acido acetilsalicilico, el mivacurio, los anestesicos locales de tipo ester, la amitriptilina, la cocaina, la heroina y varios farmacos anticonvulsivantes (7).
Se determinaron los niveles de BChE plasmatica utilizando el kit Colinesterasa (GT Lab[R]), metodo cinetico por espectrofotometria a 405 nm, pH 7.7 y 25[grados]C (Ellman et al., 1961).
Serum BChE activity in PD patients were lower than in healthy controls.
BChE is the main enzyme that metabolizes cocaine in plasma in both humans and other species.
In human lung adenocarcinoma cell line OM, at least four genes ( MME , SI , BCHE , and KNG ) were involved in carcinogenesis.
La deteccion analitica de plaguicidas es un recurso mas costoso que la medicion de BChE. El metodo aplicado en el presente trabajo, HPLC Ms-Ms provee un 100% de exactitud en la confirmacion diagnostica de la presencia del carbofuran, pero otros metodos analiticos mas accesibles (cromatografia en capa fina TLC, cromatografia gaseosa GC (12), HPLC- UV (22)), son tambien validos.
officinalis showed moderate BChE inhibition; [IC.sub.50] values of 97.33 [+ or -] 5.07 [micro]g/ml and 132.00 [+ or -] 12.70 [micro]g/ml, respectively.
Among the various biomarkers of pesticide exposure, the family of cholinesterase viz., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) has widely been used as biomarkers to evaluate the noxious effects of pesticides i.e.
Para as analises da atividade da butirilcolinesterase serica (BChE) e dos niveis de peroxidacao lipidica atraves das substancias reativas ao acido tiobarbiturico (TBARS), 3mL de sangue foram acondicionados em tubos sem anticoagulante, obtendo-se o soro por centrifugacao.