ABCG2

(redirected from BCRP1)

ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
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References in periodicals archive ?
BCRP (ABCG2) Blood [25] Diclofenac, an analgesic mainly used against cancer-associated chronic pain, is efficiently transported by murine BCRP1 and moderately by human BCRP [39].
Sorrentino, "Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo," Proceedings of the National Academy of Sciences of the United States of America, vol.
Some genes are relevant in the context of MDR, such as: CYP3A4, GSTP1, NR112 (PXR), 7XNRD1, ABCG2 (BCRP1), ABCB6, UBC, CYP1A1, ABCB1 (P-gp), CASP-3, and CASP-8.