ABCG2

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ABCG2

A gene on chromosome 4q22, which encodes a xenobiotic transporter protein of the ATP-binding cassette (ABC) superfamily, White subfamily. It plays a major role in multi-drug resistance to chemotherapeutics, and is highly expressed in the placenta, but its role there is unknown.
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References in periodicals archive ?
repo transactions generate a restricted deposit in BCRP, which is also included in the IEAs.
One of the downstream targets for AhR is BCRP encoded by ABCC3 gene [159-161].
Feddema et al., "Intestinal breast cancer resistance protein (BCRP)/Bcrp1 and multidrug resistance protein 3 (MRP3)/Mrp3 are involved in the pharmacokinetics of resveratrol," Molecular Pharmacology, vol.
Knockout rat models are a new and emerging tool in drug discovery and development, and Transposagen's p53 and Bcrp TGEM Knockout Rat Models are expected to become widely accepted for research in oncology and other therapeutic areas."
The BCRP says that the annualized growth rate for the country in the period January 2006 through August 2006 was 7.1 percent.
The banning orders were issued by the Safer Swansea Business Crime Reduction Partnership (BCRP), a consortium of shopkeepers, police, West Wales Chamber of Commerce, Swansea Council and the MRS Storenet Radio Communications.
Drugs that inhibit P-gp, BCRP, or inhibit both CYP3A and UGT1A1 may significantly increase the concentrations of components of Biktarvy.
The ATP-binding cassette sub-family G member 2 (ABCG2) was first discovered in doxorubicin-resistant breast cancer cells, so it was also termed breast cancer resistance protein (BCRP) (Doyle et al., 1998), being important in clinical drug resistance.