BCNU


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carmustine

 [kahr-mus´tēn]
a cytotoxic alkylating agent of the nitrosourea group, used as an antineoplastic agent, primarily against brain tumors, multiple myeloma, colorectal carcinoma, Hodgkin's disease, and non-Hodgkin's lymphomas. Called also BCNU.

car·mus·tine

(kar-mŭs'tēn),
An antineoplastic agent.
Synonym(s): BCNU

BCNU

A chemotherapeutic related to lomustine (CCNU) and semustine, which partially overlaps the activity/toxicity of alkylating agents.
 
Indications
Hodgkin lymphoma, non-Hodgkin lymphoma, melanoma, myeloma, brain tumours, gastrointestinal carcinomas; BCNU crosses the blood-brain barrier and may be used for meningeal leukaemia and brain tumours.
 
Side effects
Nausea, vomiting, decreased platelets, reduced WBCs, secondary leukaemia, pulmonary fibrosis, renal failure.

BCNU

Bis-chlorethylnitrosourea, carmustine A chemotherapeutic related to lomustine–CCNU and semustine, which partially overlaps the activity/toxicity of alkylating agents Indications Hodgkin's disease, possibly NHL, melanoma, myeloma, brain tumors, GI carcinomas; BCNU crosses the blood-brain barrier and may be used for meningeal leukemia and brain tumors Side effects N&V, ↓ platelets, ↓ WBCs, 2º leukemia, pulmonary fibrosis, renal failure
References in periodicals archive ?
Sartorelli, "Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine[TM] and BCNU," Biochemical Pharmacology, vol.
Smaller numbers of members of other unions, including the Communication, Energy and Paperworkers [CEP], BCNU, OPEU, International Brotherhood of Electrical Workers, Pulp and Paper Workers, and IWA, also struck.
In the mean time, the findings of a potent cytotoxic activity of D-fraction, its potentiation with vitamin C, and its chemosensitizing effect on certain anticancer drugs (e.g., BCNU) are significant and may have clinical implications, particularly in a treatment of prostate cancer patients.
Vincristine, BCNU, doxorubicin, and predisone (VBAP) combination in the treatment of relapsing or resistant multiple myeloma: a Southwest Oncology Group Study.
"In marked contrast to the many toxic effects commonly experienced by patients treated with systemic or intra-arterial BCNU therapy, no significant adverse effects were associated with these implants," he adds.
Los oligodendrocitos constituyen otro de los principales blancos de destruccion de los agentes farmacologicos empleados en la quimioterapia y son especialmente vulnerables al carmustine (BCNU), rutinariamente usado para combatir tumores cerebrales y los linfomas de Hodgkin y no Hodgkin (31).
Similar results, but involving chemotherapy, were reported for patients with recurrent glioblastoma studied with quantitative FDG-PET before and after a single cycle of 1, 3-bis-(2-chloroethyl)-1-nitrosourea (BCNU).
Rituximab (Rituxan), temozolomide (Temodar), cytarabine, carmustine (BCNU), and cisplatin have also been used in various centers.
Not all Net acronyms are, strictly, acronyms -like BCNU for "be seeing you".
Despite surgical resection of GBM tumor followed by radiotherapy and chemotherapy (i.e., carmustine (BCNU) and temozolomide), recurrences are inevitable [75, 76].