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a cytotoxic alkylating agent of the nitrosourea group, used as an antineoplastic agent, primarily against brain tumors, multiple myeloma, colorectal carcinoma, Hodgkin's disease, and non-Hodgkin's lymphomas. Called also BCNU.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


An antineoplastic agent.
Synonym(s): BCNU
Farlex Partner Medical Dictionary © Farlex 2012


A chemotherapeutic related to lomustine (CCNU) and semustine, which partially overlaps the activity/toxicity of alkylating agents.
Hodgkin lymphoma, non-Hodgkin lymphoma, melanoma, myeloma, brain tumours, gastrointestinal carcinomas; BCNU crosses the blood-brain barrier and may be used for meningeal leukaemia and brain tumours.
Side effects
Nausea, vomiting, decreased platelets, reduced WBCs, secondary leukaemia, pulmonary fibrosis, renal failure.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Bis-chlorethylnitrosourea, carmustine A chemotherapeutic related to lomustine–CCNU and semustine, which partially overlaps the activity/toxicity of alkylating agents Indications Hodgkin's disease, possibly NHL, melanoma, myeloma, brain tumors, GI carcinomas; BCNU crosses the blood-brain barrier and may be used for meningeal leukemia and brain tumors Side effects N&V, ↓ platelets, ↓ WBCs, 2º leukemia, pulmonary fibrosis, renal failure
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Sartorelli, "Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine[TM] and BCNU," Biochemical Pharmacology, vol.
Smaller numbers of members of other unions, including the Communication, Energy and Paperworkers [CEP], BCNU, OPEU, International Brotherhood of Electrical Workers, Pulp and Paper Workers, and IWA, also struck.
In the mean time, the findings of a potent cytotoxic activity of D-fraction, its potentiation with vitamin C, and its chemosensitizing effect on certain anticancer drugs (e.g., BCNU) are significant and may have clinical implications, particularly in a treatment of prostate cancer patients.
Vincristine, BCNU, doxorubicin, and predisone (VBAP) combination in the treatment of relapsing or resistant multiple myeloma: a Southwest Oncology Group Study.
"In marked contrast to the many toxic effects commonly experienced by patients treated with systemic or intra-arterial BCNU therapy, no significant adverse effects were associated with these implants," he adds.
Similar results, but involving chemotherapy, were reported for patients with recurrent glioblastoma studied with quantitative FDG-PET before and after a single cycle of 1, 3-bis-(2-chloroethyl)-1-nitrosourea (BCNU).
Rituximab (Rituxan), temozolomide (Temodar), cytarabine, carmustine (BCNU), and cisplatin have also been used in various centers.
Not all Net acronyms are, strictly, acronyms -like BCNU for "be seeing you".
Despite surgical resection of GBM tumor followed by radiotherapy and chemotherapy (i.e., carmustine (BCNU) and temozolomide), recurrences are inevitable [75, 76].