BCL7A

BCL7A

A gene on chromosome 12q24.1 that is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line.

Molecular pathology
BCL7A is thought to be involved in the pathogenesis of a subset of high-grade B-cell non-Hodgkin lymphoma.
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To study disease mechanisms, we chose a gene bcl-7 (mammalian BCL (B cell lymphoma) gene homolog), which is homologous to human BCL7 gene family members (BCL7A, BCL7B and BCL7C).
However, EBV is associated with epigenetic changes of apoptosis (DAPK, BNIP3, FAM3B HRK, IL15RA, MINT31, p16, p73, PTEN, and RASSF1A), cell cycle regulation (APC, p15, p16, p57, and p73), cell proliferation (E-Cadherin, HRASLS, IL15RA, MINT31, NKX3.1, RUNX3, TIMP2, and TIMP3), cell signalling (14-3-3 Sigma, CSPG2, MINT1, MINT2, and PLXND1), cell adhesion (EPHB6, FLNC, FSD, REC8, and CSPG2), migration (EPHB6), interaction (MDGA2, THBS1), DNA repair (HMLH1, MGMT), and many other epigenetic changes (BCL7A, BLU, CHFR, CXXC4, GSTP1, HLTF, HOXA10, IHH, MARK1, MINT25, PAX5-[beta],SCARF2, SSTR1, THBD, and WNT5A) [17, 40,190,191,194, 204-211].
As can be expected, these genes can be assigned to different functional groups such as cell death regulators (CASP2, ING2, MDM4, NAIP), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, P0LR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), oxidative stress response (SPATS2L, GSTT2B, NQO1), DNA maintenance and processing (BAHCC1, FANCA, H1ST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), blood coagulation (FGA, MATR3, PROCR, P1K3CG), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, T1CAM2), cytoskeletal components (BCL7A, DYNC1LI2, SEPT10, SEPT11), transport functions (ABCC1, FXYD2, S100A6, SCNN1G, XP05), or others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
Genes of diverse functional groups and signaling routes appeared: Cytoskleleton (BCL7A, DYNC1L12, SEFT10, SEPT11), transcriptional and translational regulation (DEPDC1, GABPB1, LHFPL2, NFIB, POLR3C, RPL34, RPS3A, RPS21, RPS25, TFDP2, TRIM24, ZBTB1, ZBTB38, ZFP112), cell death (CASP2, INC2, MDM4, NAIP), DNA maintenance and processing (BAHCC1, FANCA, HIST1H3G, IK, KDM4C, MCM7, PRB3, RNASEH2B, SNRPE, TFDP2), signal transduction (ANXA2, ARHGAP19, C7orf47, CCDC50, DTX3, FHL2, P1K3CG, RALB, TICAM2), transport functions (ABCC1, FXYD2, S100A6, SCNN1C, XP05), oxidative stress response (SPATS2L, GSTT2B, NQ01), blood coagulation (FGA, MATR3, PROCR, PIK3CG), and others (ADAM22, ALDH3A2, FAM161A, HDDC2, HLA-F).
TABLA III PATRON DE LATENCIA DEL VIRUS EPSTEIN BARR Y NEOPLASIAS ASOCIADAS Latencia Genes virales Neoplasias asociadas expresados I EBNA-1 Linfoma de Burkit EBERs BARF II EBNA-1 Linfoma de Hodgkin EBERs Cancer nasofaringeo LMP-1 Linfoma periferico LMP-2 T/NK BARF III Todos EBNAs Linfomas asociados a EBERs SIDA LMP-1 Desordenes LMP-2 linfoproliferativos BARF Postransplantes TABLA IV GENES CANDIDATOS Y LINFOMAS FAMILIARES Via Genes Ciclo celular/ AICDA, BAX, BCL2,BCL2A1,BCL2L1,BCL2L2, BCL2L10, Apoptosis BCL2L11(BIM), BCL6, BCL7A, BCL7C, BCL10, CASP1, CASP14, CASP4, CASP5, CASP6, CASP7, CASP8AP2, CASP9, CCND1, LMO2, MYC, PIM1, RIPK1, RIPK2, TP53, TP53I.