BCL6

BCL6

A gene on chromosome 3q27 that encodes a zinc finger transcription factor that acts as a sequence-specific repressor of transcription. BCL6 modulates the transcription of START-dependent IL-4 responses of B cells, and interacts with various POZ-containing transcription co-repressors.

Molecular pathology
BCL6 is often translocated (e.g., t(3;14)(q27;q32); t(3;22)(q27;q11)) and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in DLCL pathogenesis.
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Immunophenotypic analysis revealed that the tumor was positive for CD20, CD79a, BCL2, BCL6, and MUM1.
It is also characterized by expression of BCL2, BCL6, CD20, CD19 and monoclonal immunoglobulin light chain.
The immunophenotype shows CD19, CD20 (Mature B cell markers) and CD10, BCL6 (Germinal center B cell markers).
Es bien conocido que FARP2 es un importante regulador de la actividad del gen MYC (8), que IRF4 es un regulador clave del desarrollo y proliferacion de linfocitos y se ha relacionado con el desarrollo de mieloma multiple y LLC (39), ya que interactua con factores de transcripcion controlando la terminacion de la senalizacion del receptor de celulas pre-B y promoviendo la diferenciacion de celulas pro-B a celulas B pequenas, ademas via Blimp1 (proteina de maduracion inducida por linfocitos B) y BCL6 (represor transcripcional requerido para celulas B del centro germinal), controla la transicion de las celulas B de memoria.
Specific activation of microRNA-127 with downreguiation of the proto-oncogene BCL6 by chromatinmodifying drugs in human cancer ceiis.
2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.
Teniendo en cuenta las grandes exigencias en equipos, tecnologia y costos de las diferentes pruebas moleculares, se desarrollo una forma mas simplificada de identificar los factores pronosticos mediante metodos inmunohistoquimicos, utilizando algoritmos como el propuesto por Hans, que estratifica los linfomas en GCB o "no GC" segun la expresion de los marcadores CD10, BCL6 y IRF4/MUM-1 (7, 8, 11).
TABLA III PATRON DE LATENCIA DEL VIRUS EPSTEIN BARR Y NEOPLASIAS ASOCIADAS Latencia Genes virales Neoplasias asociadas expresados I EBNA-1 Linfoma de Burkit EBERs BARF II EBNA-1 Linfoma de Hodgkin EBERs Cancer nasofaringeo LMP-1 Linfoma periferico LMP-2 T/NK BARF III Todos EBNAs Linfomas asociados a EBERs SIDA LMP-1 Desordenes LMP-2 linfoproliferativos BARF Postransplantes TABLA IV GENES CANDIDATOS Y LINFOMAS FAMILIARES Via Genes Ciclo celular/ AICDA, BAX, BCL2,BCL2A1,BCL2L1,BCL2L2, BCL2L10, Apoptosis BCL2L11(BIM), BCL6, BCL7A, BCL7C, BCL10, CASP1, CASP14, CASP4, CASP5, CASP6, CASP7, CASP8AP2, CASP9, CCND1, LMO2, MYC, PIM1, RIPK1, RIPK2, TP53, TP53I.
Along with the diagnosis, there is an increasing need to evaluate prognostic markers like CD10, BCL2, BCL6 and MUM1 to subcategorize DLBCL into Germinal Centre (GC) type or Activated B Cell (ABC) type as they have different survival rates.
BCL2, BCL6, MYC, MALT 1, and BCL10 rearrangements in nodal diffuse large B-cell lymphomas: a multicenter evaluation of a new set of fluorescent in situ hybridization probes and correlation with clinical outcome.
Microscopically, the thyroid gland was infiltrated by a diffuse proliferation of atypical, large lymphoid cells Integrated histological and immunohistochemical analyses led to the diagnosis of diffuse large B-cell lymphoma (DLBCL) with a high proliferation index (Ki-67: 80%) and positive CD20 and BCL6 (Figure 1).
Work from a research team led by Pierre Vanderhaeghen of the Universite libre de Bruxelles opens new perspectives on brain development and stem cell neurobiology by discovering a gene called BCL6 as a key factor in the generation of cortical neurons during embryonic brain development.