BCL3

BCL3

A gene on 19q13.1-q13.2, which encodes a protein that functions as a transcriptional co-activator which acts by associating with NF-kappa B homodimers. BCL3’s protein product contains 7 ankyrin repeats similar to those found in I kappa B; BCL3 may interfere with binding of 50-kD subunit of NF kappa B to DNA.
References in periodicals archive ?
Moreover, downregulated BCL3, which participates in the TNF pathway in the adipose tissue of the bladder wall, leads to reduced inflammation in bladder carcinogenesis [35].
The design of a multiple drug combination for treating stage 4 bladder cancer depends on a strategy of inhibiting the highly expressed genes ADRM1, COPS5, PSMD8, SUMO2, RNF126, CALR, PDIA3, DNAJB11, HSPA5, RPN1, HSP90AA1, HSPA1B, METTL23, RARRES3, KPNA2, PSMD12, ECT2, JUN, TK1, TUBA1C, HN1, and ENO1; activating the suppressed genes BCL3, FOS, UBC, and GTF2A1; and suppressing the drug's effect on the nondifferentially expressed genes, which are the same as those in stage 1 bladder cancer.
MiR-125b-5p is upregulated in many cancers but downregulated in others, such as breast cancer, and controls many different cellular processes by targeting numerous transcription factors such as ETS1, E2F3, and BCL3 (23-25).
MiR-125b targets BCL3 and suppresses ovarian cancer proliferation.
Por otra parte, aunque no se incluyeron en esta investigacion, existen marcadores geneticos que a su vez tienen un efecto pronostico, entre ellos las mutaciones doble hit, las cuales corresponden a rearreglos entre el gen MYC/8q24 y uno de los genes BCL2, BCL3 o BCL6; estos rearreglos son comunes en las neoplasias con caracteristicas intermedias entre LBDCG y linfoma de Burkitt (49, 50).
From BCL3's 2,800 pages RCL has grown to 7,170 to accommodate: up to three full-text entries for a single title that falls into several subject areas; larger type and more generous leading; more data (including Dewey classification); audience--coded as undergrad, graduate, faculty; icons identifying holdovers from BCL3 and media--e-books, Web, and CD/DVD; and the date and Choice issue if the book was reviewed there (perhaps one-third of the total).
It is noted that a locus, representing the proto-oncogene BCL3, resides on at 19q13 (OMIM: http://www.
Stein J, Mulliken JB, Stal 5, Gasser DL, Malcom S, Winter R, Blanton SH, Amos C, Seemanova E and Hecht JT: Nonsyndromic cleft lip with or without cleft palate: evidence of linkage to BCL3 in 17 multigenerational families.
As with BCL3 comparisons, OCLC/WLN can use libraries' WorldCat or local system records.
CACD is an option of OCLC/ AMIGOS Collection Analysis Systems, which also includes Custom Cut CD, Tape Analysis and BCL3 Tape Match.
OCLC/AMIGOS Collection Analysis Systems now includes four divers collection assesment tools: Collection Analysis CD, Custom Cut CD, Tape Analysis, and BCL3 Tape Match.