There were three unique proteins to the 240 minutes TCDD treatment AHR-TAP samples, Bcl2-associated athanogene 3 (Bag3), ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (Asap2), and ubiquitin associated protein2-like(Ubap2l)(Figure 5).
Official Entrez Protein symbol number Activated leukocyte cell Alcam 11658 adhesion molecule CD166 * Cardiotrophin-like cytokine factor 1 Clcfl 56708 Bcl2-associated athanogene 3 Smarcadl SWI/SNF-related Smarcadl 13990 Arf-GAP with SH3 domain, ankyrin Asap2 211914 repeat and PH domain containing protein 2 Eef1a1 eukaryotic translation Eef1a1 13627 elongation factor 1 alpha 1 HIV TAT specific factor 1 Htatsfl 72459 Hypothetical protein LOC56279 56279 Mitochondrial ribosomal protein L40 Mrpl40 18100 Ubiquitin associated protein 2-like Ubap2l 74383 Alpha-tubulin isotype M-alpha-2 Tuba 1b 22143 Hippocalcin-like 1 Hpcall 53602 Interferon gamma inducing factor Il18 16173 Unnamed protein product A430108E01Rik 384382 (b) Note: Figure 5: TCDD 240-minute treatment data set.
In nonsyndromal CVD, an exonic deletion in the BAG3 (BCL2-associated athanogene
3) gene has been related to dilated cardiomyopathy in a multigenerational family with autosomal dominant transmission of the disease (24).
NPM-ALK has also been shown to modulate or associate with molecules involved with the ubiquitin-proteasome machinery, such as heat shock protein 90, heat shock protein 70, RanBP2, SUMO E3 ligase (small ubiquitin-like modifier), BAG2 (BCL2-associated athanogene
2), and ubiquitin carboxy-terminal hydrolase.
In a GWAS of dilated cardiomyopathy--an uncommon form of HF (1 in 2500 adults) with a risk of familial recurrence of approximately 30%--investigators discovered and replicated the results for 2 HF-associated loci near the HSPB7 [heat shock 27kDa protein family, member 7 (cardiovascular)] andBAG3 (BCL2-associated athanogene
3) genes, (6).