BCL2


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BCL2

(bē′sē-ĕl-tōō′)
n.
A gene associated with non-Hodgkin's lymphoma that normally helps regulate the life span of a white blood cell but when mutated prevents such cells from dying, allowing possible further mutations and the development of cancer.
References in periodicals archive ?
The classic immunohistochemical profile of BL is positive for BCL6, CD10, and other B-cell antigens without expression of BCL2, (37-40) although BL with positive BCL2 staining can still be diagnosed if other characteristic features of BL are present.
Following treatment with different concentrations of dioscin for 24 h, the protein expression levels of TP53, BAX, BCL2 and CASP3 (P17) were detected by Western blotting.
Our findings show that pan-BCL2 inhibition will be critical for the eradication of cancer stem cells in CML and that there is an essential link between cancer stem cell dormancy, pro-survival BCL2 isoform expression and therapeutic resistance," Jamieson said.
Causes and consequences of BCL2 overexpression in diffuse large B-cell lymphoma.
The microRNAs pair with messenger RNA to strike the right balance of BCL2.
It was then carried round the body by the bloodstream, attacking the gene BCL2 which is highly active in lymphoma patients.
MYC and BCL2 protein expression predicts survival in patients with diffuse large B-cell lymphoma treated with rituximab.
BCL2 family members and the mitochondria in apoptosis.
For 2 samples with IGH-BCL2 rearrangements, sequencing identified the structural variant because of hybrid capture of sequences of BCL2.
Similarly synovial sarcoma would express pancytokeratins, epithelial membrane antigen (EMA) and BCL2 (B-cell lymphoma-2).
PNT2258 is designed to target cancers that overexpress BCL2, an important and validated oncogene known to be dysregulated in many types of cancer.