BCL10


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BCL10

A gene on chromosome 1p22 that encodes a protein which contains a caspase recruitment domain (CARD); it induces apoptosis, activates NF-kappaB and interacts with other CARD domain proteins (e.g., CARD9, 10, 11 and 14), which are thought to act as upstream regulators in NF-kappaB signalling.

Molecular pathology
BCL10 protein product forms a complex with MALT1, a protein encoded by a gene that is translocated in MALT lymphoma and together activate NF-kappaB; deregulation of either BCL10 or MALT1 may lead to MALToma.
References in periodicals archive ?
Tobacman, "Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells," American Journal of Physiology--Gastrointestinal and Liver Physiology, vol.
Tobacman, "Bcl10 mediates LPS-induced activation of [NF-[kappa]B and IL-8 in human intestinal epithelial cells," American Journal of Physiology--Gastrointestinal and Liver Physiology, vol.
Yan et al., "Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)," Nature Genetics, vol.
The team of researchers concluded that Bcl10 is required for fatty acids to induce inflammation in the liver and insulin resistance.
"We were surprised to learn that Bcl10, a protein previously known for its critical role in immune cell response to infection, also plays a critical role in the liver's response to fatty acid," said Lucas.
Acinar differentiation, which is the most common, results in trypsin, chymotrypsin, lipase, and BCL10 positivity, making distinction from ACC challenging unless one identifies pathognomonic squamoid morules, and even primitive (blastemal) elements.
Carrageenan exposure was shown to produce NF-[kappa]B activation by three distinct mechanisms, including (1) TLR4-Bcl10-IKK[gamma]-IKK[beta]-inhibitory factor (I[kappa]B)[alpha]-NF-[kappa]B (RelA) pathway; (2) TLR4-Bcl10-NF-[kappa]B-inducing kinase (NIK)-IKK[alpha]-NF-[kappa]B (RelB) pathway; and (3) are active-oxygen-species-(ROS-) mediated pathway that involves Hsp27-IKK[beta]-I[kappa]B[alpha]-NF-[kappa]B (RelA) that does not require Bcl10 [3, 4, 7, 8].
This is the first report to address the requirement for Bcl10 as a mediator of carrageenan-induced inflammation in the in vivo animal model and extends previous findings about the mechanisms by which carrageenan produces inflammation.
Wang, "The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling," Seminars in Immunology, vol.
You et al., "CD3/CD28 costimulation-induced NF-[kappa]B activation is mediated by recruitment of protein kinase C-0, Bcl10, and I[kappa]B kinase to the immunological synapse through CARMA1," Molecular and Cellular Biology, vol.
Summary of Useful Markers for Acinar Cell Carcinoma (ACC), Pancreatic Neuroendocrine Tumor (P-NET), Solid Pseudopapillary Tumor (SPT), and Pancreatoblastoma (PB) Antibodies ACC P-NET SPT PB [beta]-catenin M or rarely N + C M N + C N + C or M+ E-cadherin + + - - or + Chromogranin - + - - or + CD10 - + + - or + Trypsin + - - + Glypican 3 + or - - - ND BCL10 + - - ND Abbreviations: +, usually more than 75% of cases are positive; /, less than 5% of cases are positive;+ or /, usually more than 50% of cases are positive; /or +, less than 50% of cases are positive; BCL10, B cell CLL/lymphoma 10;C, cytoplasmic staining;CD10, cluster of differentiation 10; CLL, chronic lymphocytic leukemia; M, membranous staining;N, nuclear staining;ND, no data.
Nuclear expression of BCL10 or nuclear factor kappaB helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphoma with and without t(11;18)(q21;q21).