CCND1

(redirected from BCL1)
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CCND1

A gene on chromosome 11q13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D1 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it also interacts with tumour suppressor protein Rb, which regulates the expression of CCND1.
 
Molecular pathology
CCND1 mutations, amplification and overexpression alter cell cycle progression, occur in various tumours and play a role in tumourigenesis.
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F through H, The atypical cells are positive for BCL6 (F) and MUM1 (G) but negative for CD10 (H) and BCL1 (data not shown) (hematoxylin-eosin, original magnification X200 [A]; original magnification X200 [B through H]).
Previous Practical Immunohistochemistry Markers for Mature B-Lymphocytic Neoplasms CLL/SLL MCL FL MZL LPL/WM CD3 - - - - - CD5 + + - - - CD10 - - + - - or + CD20 + + + + + CD23 + - + or - - or + - or + BCL1 - + - - - BCL2 + + + + + BCL6 - - + - - MIB/Ki67 + * + * + * + * + * Abbreviations: +, positive in most cases;-, negative in most cases; + or -, most cases are positive, and some cases are negative; - or +, most cases are negative, and some cases are positive; *, variable;CD, cluster of differentiation;CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; FL, follicular lymphoma;LPL/WM, lympho-plasmacytic lymphoma/Waldenstrom macroglobulinemia;MCL, mantle cell lymphoma; MZL, marginal zone lymphoma.
No consistent pattern was observed when neoplasms were stained with antibodies to carcinoembryonic antigen, S100 protein, gross cystic disease fluid protein 15, epithelial membrane antigen, BCL1, or BCL2.