CCND1

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CCND1

A gene on chromosome 11q13 that encodes a member of the highly conserved cyclin family, which regulates CDK kinases. Cyclin D1 forms a complex with and is a regulatory subunit of CDK4 or CDK6, which are required for cell cycle G1/S transition; it also interacts with tumour suppressor protein Rb, which regulates the expression of CCND1.
 
Molecular pathology
CCND1 mutations, amplification and overexpression alter cell cycle progression, occur in various tumours and play a role in tumourigenesis.
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Cyclin D1 (Bcl1, PRAD1) protein expression in low-grade B-cell lymphomas and reactive hyperplasia.
F through H, The atypical cells are positive for BCL6 (F) and MUM1 (G) but negative for CD10 (H) and BCL1 (data not shown) (hematoxylin-eosin, original magnification X200 [A]; original magnification X200 [B through H]).
Previous Practical Immunohistochemistry Markers for Mature B-Lymphocytic Neoplasms CLL/SLL MCL FL MZL LPL/WM CD3 - - - - - CD5 + + - - - CD10 - - + - - or + CD20 + + + + + CD23 + - + or - - or + - or + BCL1 - + - - - BCL2 + + + + + BCL6 - - + - - MIB/Ki67 + * + * + * + * + * Abbreviations: +, positive in most cases;-, negative in most cases; + or -, most cases are positive, and some cases are negative; - or +, most cases are negative, and some cases are positive; *, variable;CD, cluster of differentiation;CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; FL, follicular lymphoma;LPL/WM, lympho-plasmacytic lymphoma/Waldenstrom macroglobulinemia;MCL, mantle cell lymphoma; MZL, marginal zone lymphoma.
Nodal Marginal Zone Lymphoma: sIGM+, sIGD-, cIG-/+, panB+, [CD5.sup.-], [CD10.sup.-], [CD23.sup.-], [CD43.sup.-/+]; IGH and IGL gene rearrangements, BCL1 and BCL2 germline.
Mantle Cell Lymphoma: sIGM+, sIGD+, [lambda] > [kappa], panB+, [CD5.sup.+], [CD10.sup.-/+], [CD23.sup.-], [CD43.sup.+], [CD11c.sup.-], [CD25.sup.-], cyclin D1+; IGH and IGL gene rearrangements, t(11;14)(q13;q32); BCL1 gene rearrangements (CCND1/cyclinD1) common.