BCG vaccine


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BCG vaccine

 
bacille calmette-guérin vaccine, a tuberculosis vaccine containing living, avirulent, bovine-strain tubercle bacilli (Mycobacterium bovis). It may be administered percutaneously by a special technique using a multiple-puncture disk, intracutaneously, or intradermally, and it cannot be given when the patient is reactive to tuberculin, when acute infectious disease is present, or when there is extensive skin disorder. It offers some protection against tuberculosis but cannot be relied on for total control of the disease. In a high percentage of cases the vaccine causes local ulcers at the site of administration. Public health officials in the United States recommend the use of BCG vaccine only for those persons living in communities having a high rate of tuberculosis cases. After vaccination with BCG, the patient will have a positive response to tuberculin tests. See also BCG solution.

BCG vac·cine

a suspension of an attenuated strain (bacillus Calmette-Guérin) of Mycobacterium tuberculosis, bovine type, which is inoculated into the skin for tuberculosis prophylaxis.

BCG vaccine

(bē′sē-jē′)
n.
A preparation consisting of attenuated human tubercle bacilli that is used for immunization against tuberculosis.

BCG vaccine

BCG vaccine

A vaccine containing Bacille Calmette-Guérin, an attenuated strain of the bovine tubercle bacillus. The vaccine is used to confer a measure of immunity on people who, on Mantoux or Heaf testing are shown not to have had a primary infection with tuberculosis. It is equally effective in giving protection against leprosy. BCG vaccine is available in a freeze-dried form. The drug is on the WHO official list. (Leon Charles Albert Calmette, 1863–1933, French surgeon, and Camille Guerin, 1872–1961, French veterinary surgeon).

Calmette,

Leon Charles Albert, French bacteriologist, 1863-1933.
Bacille bilié de Calmette-Guérin - an attenuated strain of Mycobacterium bovis used for immunization against tuberculosis and in cancer chemotherapy. Synonym(s): Bacille Calmette-Guérin; Calmette-Guérin bacillus
Bacille Calmette-Guérin - Synonym(s): Bacille bilié de Calmette-Guérin
bacillus Calmette-Guérin vaccine - a vaccine for tuberculosis prophylaxis. Synonym(s): BCG vaccine
Calmette test - conjunctival reaction to tuberculin.
Calmette-Guérin bacillus - Synonym(s): Bacille bilié de Calmette-Guérin
Calmette-Guérin vaccine - Synonym(s): bacillus Calmette-Guérin vaccine

BCG

bacille Calmette-Guérin, an avirulent strain of Mycobacterium bovis.

BCG test
is sometimes used in the diagnosis of tuberculosis in dogs as being more reliable and sensitive than tuberculin testing.
BCG vaccination
has been used in the control of tuberculosis in cattle but has many disadvantages, especially interference with tuberculin testing, and is not recommended for use unless the prevalence of the disease is very high.
BCG vaccine
contains living BCG organisms. It was developed for use in the control of tuberculosis in humans. Contains living BCG organisms. Is used as a nonspecific stimulant to antibody production in chronic diseases, e.g. equine sarcoid and neoplasia in dogs.
References in periodicals archive ?
Immunoprophylactic trial with combined Mycobacterium leprae / BCG vaccine against leprosy: preliminary results.
BCG scare timeline:Nearly 120 pupils at Ysgol Penweddig comprehensive were being injected with the BCG vaccine, which combats tuberculosis, from Monday last week.
On the website, it says: "Studies have shown that BCG vaccine gives substantial protection in both school children and newborn infants and it has contributed to the dramatic decline in TB over the past 40 years.
The relatively low incidence of TB in the United States, coupled with uncertainties about the effectiveness of the BCG vaccine, has led the U.
president and chief executive officer of PerImmune, was responsible for the development of the Tices BCG vaccine, which is one of the leading therapeutic products for the treatment of bladder cancer.
As a result, the BCG vaccine does not induce an immune response to this protein, so deploying it as a new TB vaccine would provide additive immunity over and above that provided by BCG.
Chairman of the Southern Health Forum Ciaran Lynch appealed to the HSE to address the backlog in the provision of the BCG vaccine.
But last August, Irish health authorities suspended its BCG vaccine licence over manufacturing procedure concerns.
The group, which caused controversy when it was awarded a government contract to supply smallpox vaccine, said late on Friday it was recalling the BCG vaccine after the temporary suspension of its licence for the vaccine in Ireland.
It comes after the MCA's Irish equivalent raised concerns about the company's manufacturing procedures, and suspended its licence to supply the BCG vaccine in the Irish Republic.
PowderJect was at the centre of controversy last year when Dr Drayson gave Labour pounds 50,000 just two months after his company won a pounds 17million NHS contract for the anti-TB BCG vaccine at what some critics alleged was an inflated price.
The BCG vaccine, used against tuberculosis for more than 50 years, may still have a few tricks up its sleeve.