BCG vaccine


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BCG vaccine

 
bacille calmette-guérin vaccine, a tuberculosis vaccine containing living, avirulent, bovine-strain tubercle bacilli (Mycobacterium bovis). It may be administered percutaneously by a special technique using a multiple-puncture disk, intracutaneously, or intradermally, and it cannot be given when the patient is reactive to tuberculin, when acute infectious disease is present, or when there is extensive skin disorder. It offers some protection against tuberculosis but cannot be relied on for total control of the disease. In a high percentage of cases the vaccine causes local ulcers at the site of administration. Public health officials in the United States recommend the use of BCG vaccine only for those persons living in communities having a high rate of tuberculosis cases. After vaccination with BCG, the patient will have a positive response to tuberculin tests. See also BCG solution.

BCG vac·cine

a suspension of an attenuated strain (bacillus Calmette-Guérin) of Mycobacterium tuberculosis, bovine type, which is inoculated into the skin for tuberculosis prophylaxis.

BCG vaccine

(bē′sē-jē′)
n.
A preparation consisting of attenuated human tubercle bacilli that is used for immunization against tuberculosis.

BCG vaccine

BCG vaccine

A vaccine containing Bacille Calmette-Guérin, an attenuated strain of the bovine tubercle bacillus. The vaccine is used to confer a measure of immunity on people who, on Mantoux or Heaf testing are shown not to have had a primary infection with tuberculosis. It is equally effective in giving protection against leprosy. BCG vaccine is available in a freeze-dried form. The drug is on the WHO official list. (Leon Charles Albert Calmette, 1863–1933, French surgeon, and Camille Guerin, 1872–1961, French veterinary surgeon).

Calmette,

Leon Charles Albert, French bacteriologist, 1863-1933.
Bacille bilié de Calmette-Guérin - an attenuated strain of Mycobacterium bovis used for immunization against tuberculosis and in cancer chemotherapy. Synonym(s): Bacille Calmette-Guérin; Calmette-Guérin bacillus
Bacille Calmette-Guérin - Synonym(s): Bacille bilié de Calmette-Guérin
bacillus Calmette-Guérin vaccine - a vaccine for tuberculosis prophylaxis. Synonym(s): BCG vaccine
Calmette test - conjunctival reaction to tuberculin.
Calmette-Guérin bacillus - Synonym(s): Bacille bilié de Calmette-Guérin
Calmette-Guérin vaccine - Synonym(s): bacillus Calmette-Guérin vaccine

BCG

bacille Calmette-Guérin, an avirulent strain of Mycobacterium bovis.

BCG test
is sometimes used in the diagnosis of tuberculosis in dogs as being more reliable and sensitive than tuberculin testing.
BCG vaccination
has been used in the control of tuberculosis in cattle but has many disadvantages, especially interference with tuberculin testing, and is not recommended for use unless the prevalence of the disease is very high.
BCG vaccine
contains living BCG organisms. It was developed for use in the control of tuberculosis in humans. Contains living BCG organisms. Is used as a nonspecific stimulant to antibody production in chronic diseases, e.g. equine sarcoid and neoplasia in dogs.
References in periodicals archive ?
BCG vaccine is given intradermally over the deltoid muscle on the left arm to infants within 5 days after birth at the maternity hospital.
Another Saudi mother from Jeddah voiced her concern over the absence of the vaccine saying: "I have been visiting and calling several government clinics that offer the vaccines free of charge to Saudi nationals only to find out that they are still waiting to receive the BCG vaccine from the Ministry of Health without giving us any reason for the delay.
Palmer and his team are collaborating with scientists at USDA's National Wildlife Research Center in Fort Collins, Colorado, to develop a new bait to deliver the BCG vaccine to deer.
The antigens used in IGRAs are highly specific for TB and absent from the BCG vaccine.
Though in the mouse model, only ~1 unit log reduction in peak lung bacillary load is achievable by BCG vaccine, the reduction is 2-3 log unit in immunized guinea pigs which provides a wider spectrum for evaluating pigs efficacies of the vaccine candidates (36,38).
Doctors then decide whether the pupils will need to be given the BCG vaccine which protects against TB.
The scientists gave the new vaccine to 17 volunteers who had received the BCG vaccine in the past--as recently as within a year or as long as 38 years ago.
Although the BCG vaccine offers protection against the most serious forms of TB in childhood, its efficacy wanes over a period of 10-15 years after the vaccination.
But last August Irish health authorities suspended its BCG vaccine licence over manufacturing procedure concerns.
She developed an infection after being given a BCG vaccine against tuberculosis.
Oligoarticular aseptic arthritis, for example, has been seen in bladder cancer patients who have been treated with BCG vaccine.
Also at the conference, WHO experts advised that inoculations of the BCG vaccine, used to prevent the disease, be administered only once during a person's life, as multiple inoculations have been shown to be ineffective.