Babies weighing >2.5 Kg in the study were 91 (82.72%) and 19 (17.25%) were between 2 to 2.5 Kg who had undergone BCG Vaccination
. Scar failure rate in babies weighing < 2.5 Kg was 10.5%  and 3.2%  in babies weighing > 2.5 Kg.
"This will be used to inform an updated recommendation to the Department regarding the future provision of BCG vaccination
Among 214 participants who reported prior BCG vaccination
, 124 (57.9%) were negative on all three tests (TST, IGRAs, and T.SPOT).
The patient had been given BCG vaccination
on D2 of life, and there was no significant lesion in the left deltoid region currently [Figure 1].
Literature suggest that lymphadenitis mainly occurs in healthy neonates.1,2,8 In cases of preterm and low birth weight babies, inoculation is delayed to avoid severe side effects; as in cases of immunodeficiency or in patients with HIV, BCG vaccination
can lead to dissemination and in these cases, definitive diagnosis can be made by gene therapy.2,8 Only cases of dissemination need ATT and studies giving ATT in all cases of BCG lymphadenitis,8,10 fail to show earlier resolution.
Since the patient with a history of BCG vaccination
had no history of tuberculosis contact and was not living in high tuberculosis burden countries [5,6], BCG osteomyelitis was primarily suspected.
IGRAs are rarely influenced by prior BCG vaccinations
and, thus, superior to TST for immunocompromised conditions .
"Many groups are looking at the ability of BCG vaccination
to reverse autoimmunity," says Faustman, who is an associate professor of Medicine at Harvard Medical School.
There was a high BCG vaccination
coverage (the first administered vaccine) and a low measles vaccination coverage (the last administered vaccine) estimated in a survey indicating a high dropout rate, ranging from 14% in Syedpur to 36% in Dhaka's zone 8.
If an individual either has a history of BCG vaccination
or is unlikely to return to have their TST read, then it is strongly recommended to use the IGRA as the test of choice.
The protective effect of SDR and BCG vaccination
appears to be additive, approximating 80%.12,13Considering these findings, it is imperative that future leprosy control strategy should include chemoprophylaxis and immunoprophylaxis of contacts.
In bivariate analysis, the country-wide percentage of women obtaining facility-based delivery was significantly associated with the national percent of children aged 12-23 months who were fully vaccinated (Pearson R = 0.32, p=.060) and who received BCG immunization (Pearson R = 0.44, p=.002); countries with higher rates of facility-based delivery also had higher rates of full vaccination and BCG vaccination
. This relationship did not extend to other immunizations.