BAIAP2

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BAIAP2

A gene on chromosome 17q25 that encodes an adapter protein which links membrane-bound small G proteins to cytoplasmic effector proteins. BAIAP2 is needed for CDC42-mediated reorganisation of the actin cytoskeleton and for RAC1-mediated membrane ruffling; it is involved in regulating the actin cytoskeleton by WASF family members and the Arp2/3 complex, plays a role in neurite growth and in reorganising the actin cytoskeleton in response to bacterial infection. It acts syngeristically with ENAH to promote filipodia formation.
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[14] observed phenylalanine uptake in a gap1ssy1 strain overexpressing BAP2, Grauslund et al.
In the present study, we focused on the participation of GAP1 [16], BAP2 [15,17], and AGP1 [13,18] in L-phenylalanine transport.
[14] employed overexpression and deletion to show that BAP2, AGP1, BAP3, and TAT2 could be involved in phenylalanine uptake.
In order to study the physiological functions of GAP1, BAP2, and AGP1 in L-phenylalanine transport, we examined the kinetics, substrate specificity, and regulation of these systems, employing isogenic haploid strains with the respective genes disrupted individually and in combination.
The Saccharomyces cerevisiae strains used in this study are all isogenic with the "wild type" parental strain Y294, MAT [alpha] ura3-52 leu 2-3,112 his3-[DELTA]1 trp1-289 [17] except for the mutations mentioned; Y294[DELTA]bap2 with bap2::URA3; Y294[DELTA]gap1 with gap1::LEU2; Y294d[DELTA]bap2[DELTA]gap1 with bap2::URA3 and gap1::LEU2; [17]; Y294 [DELTA]agp1 with agp1::URA3, and Y294[DELTA]agp1[DELTA]gap1 with agp1::HIS3 and gap1::LEU2.
The Solver program was used to simultaneously fit the Y294 with the parameters obtained from the Y294[DELTA]bap2 data for the two permeases and by adjusting the Bap2 parameters to obtain the best fit.
Disruption of BAP2 in a gap1 Strain Confers Resistance to Toxic Analogues of Leucine and Phenylalanine.
BAP2: A manufacturing line similar to BAP1, but with realistic real-world processing times: the times are offset by a minimum (a task cannot be executed in less time), and the distributions are truncated (a task has a finite duration).
BAP3: A manufacturing line similar to BAP2, but each workstation can rework a product just finished if it fails a quality inspection, or a product produced by the workstation can be completely rejected (Table I).
Processing Rejection times rate BAP3 Machine BAP1 BAP2, 3 Quality Final 1 1.0 1.090+logn(0.080, 3 % 2 % 0.21)/0.41 2 1.1 1.080+logn(0.075, 2 % 2 % 0.17)/0.48 3 1.2 1.071+logn(0.068, 2 % 2 % 0.17)/0.58 4 1.3 1.069+logn(0.059, 2 % 2 % 0.17)/0.67 5 1.4 1.058+logn(0.058, 2 % 2 % 0.17)/0.74 4.
[B.sub.i] evaluations estimated estimated allowed (1) Pareto set [T.sub.R] BAP1 35, 30, 25, 656 250 340 55 0.905 25 BAP2 30, 25, 20, 300 000 280 38 0.719 20 BAP3 25, 20, 15, 112 500 520 44 0.620 15 BAP4 15 for all > 1 050 34 5.023 i [10.sup.17] BAP5 15 for all > 400 59 4.043 i [10.sup.17] (1) To obtain estimated Pareto set Similar plots for BAP2, BAP3, BAP4 and BAP5 are shown in Figs.
No shoots were regenerated when using medium containing 17(BAP0.5+2,4-D0.1), 18(BAP1.0+2,4-D0.5) or 20(BAP0.5, 2,4 D0.5), However, medium 19 (BAP2.0+2,4-D0.1),21(BAP1.0+2,4-D0.5) and 22(BAP2.0+2,4-D0.5) produced low number of shoots, the highest number of shoot per explant was obtained by medium 22 (0.58 shoot per explant).