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A gene on chromosome 22q12.2 that encodes a putative regulator of the Hippo/SWH (Sav/Wts/Hpo) signalling pathway, which plays a key role in tumour suppression by restricting proliferation and promoting apoptosis. NF2 may act as a membrane-stabilising protein, and it may inhibit PI3 kinase by binding to AGAP2 and downregulating its stimulating activity. NF2 suppresses cell proliferation and tumourigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.

Molecular pathology
NF2 defects cause:
• Neurofibromatosis 2;
• Schwannomatosis; and
• Mesothelioma (some cases).


Bilateral acoustic neurofibromatosis. See Neurofibromatosis, type 2.
References in periodicals archive ?
As well as withdrawing Banfs funding, the BSP has told the Birmingham Community Empowerment Network (B:cen) that its core funding will cease.
BANF recently elected a new management committee, which is understood to be concerned at the lack of progress made by the organisation since Mr Rice took up his position just over a year ago.
He argues that if another city department takes on the BANF or B: Cen role then, under employment law, they have a duty to take the staff into that department.
Chairman of BANF Victor Cox, who also chairs the Falcon Lodge Neighbourhood Forum, said members were "very concerned"
Both B: Cen and Banf have encouraged members to debate the issue of whether they should be consulted over how the city is run.
Members of the Birmingham Association of Neighbourhood Forums, or BANF, are backing calls for a referendum on how the city's mayor is elected.
Victor Cox, aged 54, chairman of BANF and Falcon Lodge Neighbourhood Forum, said: "I am for the referendum because people need to be given the choice and this meeting proved how interested people are in the issue.