BAIAP2

BAIAP2

A gene on chromosome 17q25 that encodes an adapter protein which links membrane-bound small G proteins to cytoplasmic effector proteins. BAIAP2 is needed for CDC42-mediated reorganisation of the actin cytoskeleton and for RAC1-mediated membrane ruffling; it is involved in regulating the actin cytoskeleton by WASF family members and the Arp2/3 complex, plays a role in neurite growth and in reorganising the actin cytoskeleton in response to bacterial infection. It acts syngeristically with ENAH to promote filipodia formation.
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RAPGEF1, TSC2, INPPL1, BAIAP2, PLXNA2, CHMP1A, and RTN4R were related to the two pathway enriched in liver.
Other candidate genes for ADHD studied include brain derived neurotrophic factor (BDNF), brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2), circadian locomotor output cycles kaput (CLOCK), Zinc finger protein 804A gene (ZNF804A), amphetamine-regulated transcript (CARTPT), and C-kinase-1 (PICK1) genes, Cholinergic receptor.
BAIAP2 is thought to be associated with cerebral asymmetry.
BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects.