BAIAP2

BAIAP2

A gene on chromosome 17q25 that encodes an adapter protein which links membrane-bound small G proteins to cytoplasmic effector proteins. BAIAP2 is needed for CDC42-mediated reorganisation of the actin cytoskeleton and for RAC1-mediated membrane ruffling; it is involved in regulating the actin cytoskeleton by WASF family members and the Arp2/3 complex, plays a role in neurite growth and in reorganising the actin cytoskeleton in response to bacterial infection. It acts syngeristically with ENAH to promote filipodia formation.
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RAPGEF1, TSC2, INPPL1, BAIAP2, PLXNA2, CHMP1A, and RTN4R were related to the two pathway enriched in liver.
BAIAP2 is thought to be associated with cerebral asymmetry.
BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects.