BAG4

BAG4

A gene on chromosome 8p11.23 that encodes BCL2-associated athanogene 4, a ubiquitous protein that inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release and prevents TNFRSF1A signalling.
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It has also been observed that the lenses implanted in the ciliary sulcus induce more rise in intraocular tension than the lenses implanted in the capsular bag4,5.
Notably, circ_001569 did not directly affect miR-145 expression, but through a sponge mechanism it inhibited its posttranscriptional activity; accordingly, it upregulated its targets E2F5 (E2F transcription factor 5), BAG4 (BCL2-associated athanogene 4), and FMNL2 (formin-like 2), which were responsible for cell proliferation and invasion promotion by circ_001569 [148].
HSPA1L and the cochaperones, BAG2 and BAG4, have all been shown to modulate PINK1-Parkin mediated mitophagy [78, 79].
In colorectal cancer (CRC), hsa_circ_001569 acts as the positive regulator of cell proliferation and invasion via "sponging event" of miR-145, which upregulates functional targets of E2F5, BAG4, and FMNL2 [17].
hsa_circ_001569 was reported to act as a positive regulator of proliferation and invasion of CRC cells; it functions as a sponge of miR-145, and therefore, targets upregulated miR-145, such as E2F5, BAG4, and FMNL2 [17].
They found that at least four genes, called TOMM7, HSPAI1L, BAG4 and SIAH3, may act as helpers.
Turning off some genes, such as TOMM7 and HSPAI1L, inhibited parkin tagging whereas switching off other genes, including BAG4 and SIAH3, enhanced tagging.
"Women in Irish Mythology." The Crane Bag4 (1980): 7-11.
Hsa_ circ_001569 may act as a miR-145 sponge and represses the transcriptional activities of miR-145, enabling upregulation of miR-145 target genes E2F5, BAG4, and FMNL2.