BAG3


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BAG3

A gene on chromosome 10q25.2-q26.2 that encodes BCL2-associated athanogene 3, a protein that inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release and has anti-apoptotic activity.
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References in periodicals archive ?
It is estimated a similar number of DCM patients with BAG3 mutations exist in Europe.
Currently DCM patients with a BAG3 mutation are treated with standard of care for heart failure.
Development of a BAG3 gene replacement therapy for patients with DCM that carry BAG3 mutations could potentially prevent progression of disease in this otherwise healthy population of young adults.
Bernier, "Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3," International Journal of Biochemistry and Cell Biology, vol.
Kohn, "Caught in the middle: the role of Bag3 in disease," Biochemical Journal, vol.
Takayama, "BAG3 regulates motility and adhesion of epithelial cancer cells," Cancer Research, vol.
Liu, "MIR-143 enhances the antitumor activity of shikonin by targeting BAG3 expression in human glioblastoma stem cells," Biochemical and Biophysical Research Communications, vol.