ARID2

(redirected from BAF200)

ARID2

A gene on chromosome12q12 that encodes as protein involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). ARID2 is required for stabilising the SWI/SNF chromatin remodelling complex SWI/SNF-B (PBAF); it may play a role in targeting the complex to different genes, and may be involved in regulating transcriptional activation of cardiac genes. ARID2 is highly expressed in the heart and testes.
References in periodicals archive ?
Murray et al., "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes," Genes & Development, vol.