In mammals, this family includes six members, Nrf1, (26) Nrf2, (27) Nrf3, (28) nuclear factor erythroid 2 (NF-E2) p45 subunit, (29,30) BTB and CNC homolog 1 (Bach1), (31) and Bach2
. (31) All these proteins contain a CNC domain and bZIP domain (Fig.
The neoplastic cells show an immunophenotype similar to that of low-grade nodal FL (NFL) by expressing CD20 (Figure 4), CD79a, CD10 (Figure 5), BCL-6, BCL-2 (Figure 6), and BACH2
, and show a lack of expression for CD5, CD23, CD43, BCL-1 (cyclin D1), MUM-1, Blimp-1, and T-cell markers.
Notably, all the 10 B cell gene signatures (BANK1, HVCN1, CD79B, RALGPS2, FCRL3, CD79A, BACH2
, FCRL1, BLK, and BTLA) showed negative expression correlations with the PLK1 expression in ESCA, and 9 did in LUSC and STAD (Pearson correlation, FDR<0.1) (Figure 1(c)).
The 20 most up- and down-regulated genes include significant changes in expression of genes related to apoptosis (FDRX) B-cell functions (FCRLA, IGHM, PAX 5, BACH2
, MS4A1, and POU2AF1), inflammation (ITLN1, CCR7), hemoglobin synthesis (XK and RHD), and induced by oxidative stress (SESN3).
The highest p300 enrichment in SEs was associated with the Bach2
locus regardless of the lineage subset of [CD4.sup.+] T cells.
Within the nucleus, B-zip proteins BACH1 and BACH2
can form dimers with Maf proteins through their BTB domain and compete for binding to the ARE, preventing Nrf2 binding and activation of transcription [46-48].
The network also includes genes that were previously not thought to play any role in chondrogenesis like Fbxl18, Tle3, Rad51c, and Bach2
and we have validated two of these novel targets in this study.
The NF-kappaB subunit c-Rel regulates Bach2
tumour suppressor expression in B-cell lymphoma.
The virus also landed in the BACH2
gene at least 15 times.
The only pair of negative association is between the Gclm and Metf2c, which in turn is positively associated with Bach2
DOHA A group of scientists, including Sidra Medical and Research Center's Chief Research Officer Francesco M Marincola, has discovered that a gene called Bach2
may play a central role in the development of a range of allergic and auto-immune diseases, such as multiple sclerosis, asthma, Crohn's disease, celiac disease, and Type-1 diabetes.