Structure and mechanism of brca1 brct domain recognition of phosphorylated bach1
with implications for cancer.
In mammals, this family includes six members, Nrf1, (26) Nrf2, (27) Nrf3, (28) nuclear factor erythroid 2 (NF-E2) p45 subunit, (29,30) BTB and CNC homolog 1 (Bach1
), (31) and Bach2.
In fact, hepatic HMOX1 has been widely studied, and a wealth of scientific evidence has shown that HMOX1, mainly through a mammalian transcription factor Bach1
, can protect cells from oxidative stress and apoptosis [23-26].
Tyrrell, "The role of Bach1
in ultraviolet A-mediated human heme oxygenase 1 regulation in human skin fibroblasts," Free Radical Biology & Medicine, vol.
Sodhi et al., "Crosstalk between EET and HO-1 downregulates Bach1
and adipogenic marker expression in mesenchymal stem cell derived adipocytes," Prostaglandins and Other Lipid Mediators, vol.
For instance, repression of BTB domain and CNC homolog (Bach1
), a nuclear inhibitor of Nrf2, in combination with traditional Nrf2 activators, has shown promising results in neurodegenerative disease models for safely increasing the efficiency and biological activity of these agents .
BTB and CNC homology 1 (Bach1
) is a basic leucine zipper transcription factor that heterodimerizes with small Maf proteins and binds to the antioxidant responsive element (ARE) to repress the expression of genes encoding antioxidant proteins [12, 13].
In response to oxidative stress, regulatory proteins such as NRF1, NRF3 and BACH1
bind to AREs and compete for binding with NRF2.
The let-7 microRNA enhances heme oxygenase-1 by suppressing Bach1
and attenuates oxidant injury in human hepatocytes.
Overexpression of transcription factor BACH1
in fetal Down syndrome brain.
Jaiswal, "Antioxidant-induced phosphorylation of tyrosine 486 leads to rapid nuclear export of Bach1
that allows Nrf2 to bind to the antioxidant response element and activate defensive gene expression," Journal of Biological Chemistry, vol.