BACE2


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BACE2

A gene on chromosome 21q22.3 that encodes beta secretase 2, a transmembrane enzyme responsible for the proteolysis of the amyloid precursor protein, leading to the generation and extracellular release of beta-cleaved soluble AP. It is expressed at low levels in most peripheral tissues and at higher levels in the colon, kidney, pancreas, placenta, prostate (in benign and malignant ducts), stomach and trachea.
References in periodicals archive ?
BACE2 and RUNX1 showed variable low levels of expression in left dental gyrus (-2.431/-1.355) respectively.
In the first component, DSCR1, 8, 10, BACE2, ERG and RUNK1 genes were grouped, while in the second component DSCR4 and ETS2 genes were included.
BACE2 can be found in the majority of peripheral tissues with different expression levels, with kidney tissues showing the highest level of expression [7].
Here, we reported the application of the ET method on BACE1 and BACE2 to extract the conservative and distinctive features of both enzymes in terms of molecular sequences and 3D structures that would provide beneficial details for the design of selective drug targeting BACE1 and BACE2.
Human BACE1 and BACE2 sequences with UniProt accession numbers P56817 and Q9Y5Z0, respectively, were used as query sequences for BLASTP [12] searches against the UniProt database [13].
Based on NCBI database, the screened differentially expressed genes Apaf1, Bace2, and Plcb4 were enriched in the "Alzheimer's diseasereference pathway." That is, these genes not only play an important role in the development of AD, but also their genes expression products were involved in apoptosis, A[beta] formation, and cell or organelle membrane damage.
Though Bace2, the homologue of Bacel, is also expressed in the brain, its potential role in AD has not been clarified completely.
ME may negatively regulate the expression of Apafl, Bace2, and Plcb4 genes, thereby delaying the development of AD.
The findings suggest that the roles of the gene HKDC1 in glucose metabolism and BACE2 in insulin secretion are more important during pregnancy versus the non-pregnant state - across all ethnicities studied.
The researchers then discovered that mice that lacked Bace2 had larger islets and the beta cells in the islets increased in number, a process known as proliferation or regeneration.
They also found that these mice were able to clear glucose from the blood more efficiently than control mice with Bace2.
Stoffel and his team next aimed to inhibit Bace2 in an effort to control and promote the growth of beta cells.