BACE2


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BACE2

A gene on chromosome 21q22.3 that encodes beta secretase 2, a transmembrane enzyme responsible for the proteolysis of the amyloid precursor protein, leading to the generation and extracellular release of beta-cleaved soluble AP. It is expressed at low levels in most peripheral tissues and at higher levels in the colon, kidney, pancreas, placenta, prostate (in benign and malignant ducts), stomach and trachea.
References in periodicals archive ?
8 ng/ml active IDE and has minimal cross reaction with Neprilysin, TACE, b-Secretase, ADAM10 and BACE2.
Researchers found variants in two genes - HKDC1 and BACE2 - that were associated with measures of glucose and insulin levels of pregnant women but not associated with these measures in the rest of the population, including people with type 2 diabetes.
The findings suggest that the roles of the gene HKDC1 in glucose metabolism and BACE2 in insulin secretion are more important during pregnancy versus the non-pregnant state - across all ethnicities studied.