MFGE8

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MFGE8

A gene on chromosome 15q25 that encodes medin (milk fat globule-EGF factor 8 protein), which plays a key role in maintaining epithelial homeostasis and in promoting mucosal healing. Medin promotes VEGF-dependent neovascularisation, helps remove apoptotosed cells, binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner and binds rotavirus, inhibiting its replication.
References in periodicals archive ?
Konopaske 7% decrease in GT (29) deep layer III of BA46. MacDonald 27% decrease only ML (30) for smaller spine.
Connectivity of BA46 involvement in the executive control of language.
We also found that intervention leads to reduced activity in left visual association areas (BA18, BA19), middle and superior frontal gyri (BA9, BA10, and BA46), and the thalamus (Figure 4, Table 4).
Both groups recruited a left frontoparietal network including lateral prefrontal cortex (BA46), superior frontal gyrus (BAs 8 and 6), premotor and supplementary motor cortex (BA6) and parietal areas (BAs 7 and 40).
They found that acupuncture could increase the FC between left anterior cingulate and multivarious regions such as the bilateral parietal lobe (left BA40, right BA7), right temporal lobe (BA22), left PCC (BA23), superior frontal gyrus (Ba8), left middle frontal gyrus (BA46), and bilateral caudate.
Areas of activation were observed bilaterally in the middle temporal gyrus (BA21) and the inferior frontal gyrus (BA47), the medial frontal gyrus (BA6) of the left hemisphere, the middle frontal gyrus (BA46) and the precentral gyrus (BA6)of the right hemisphere.
ALFF differed significantly between the deaf and hearing group in left Heschl's gyri (BA41) (p = 0.0059, ES = 0.94), left superior temporal gyrus (BA22) (p = 0.0003, ES = 1.27), left inferior frontal gyrus (BA44) (p = 0.0004, ES = 1.27), left inferior frontal gyrus (BA45) (p = 0.0000, ES = 2.18), left inferior prefrontal gyrus (BA47) (p = 0.0001, ES = 1.40), and left dorsolateral prefrontal cortex (BA46) (p = 0.0000, ES = 1.68) in infants with CSSHL (deaf < hearing), which are responsible for auditory, language, and executive function.
ReHo differed significantly between the deaf and hearing group in left superior temporal gyrus (BA22) (p = 0.0117, ES = 0.86), left inferior frontal gyrus (BA45) (p = 0.0038, ES = 1.00), left inferior prefrontal gyrus (BA47) (p = 0.0016, ES = 1.10), left dorsolateral prefrontal cortex (BA46) (p = 0.0076, ES = 0.91), left medial frontal gyrus (BA32) (p = 0.003, ES = 1.03), and left temporal polar gyrus (BA38) (p = 0.0102, ES = 0.88) (deaf < hearing), which are responsible for auditory processing, language perception, executive function, and behavior and decision-making.
(2016) also proposed a "Broca's complex" including BA44, BA45, BA46, BA47, the mesial segment of BA6 (i.e., the supplementary motor area) and extending subcortically toward the basal ganglia.
The method takes the region of interest (for instance, BA46), makes it the independent variable, and interrogates the database for studies showing activation of the chosen target.
The core Brodmann area (BA) in the dorsolateral prefrontal cortex is BA46. BA46 is known as anterior middle frontal gyrus.