MFGE8

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MFGE8

A gene on chromosome 15q25 that encodes medin (milk fat globule-EGF factor 8 protein), which plays a key role in maintaining epithelial homeostasis and in promoting mucosal healing. Medin promotes VEGF-dependent neovascularisation, helps remove apoptotosed cells, binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner and binds rotavirus, inhibiting its replication.
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2016) also proposed a "Broca's complex" including BA44, BA45, BA46, BA47, the mesial segment of BA6 (i.
In the current meta-analytic study it was found a major cluster of coactivation, including BA46, BA47, and BA6 in the left hemisphere.
Current results illustrate that BA47, (1) participates in a frontal language production system, which probable includes not only the classical Broca's area, but also BA46 and the medial extension of BA6, corresponding to the supplementary motor area, and some subcortical areas ("Broca complex", Ardila, Bernal, & Rosselli, 2016c) (Figure 2); (2) it also has a secondary participation in semantic processing; coactivartion with left temporal areas involved in semantic processing (BA37 and BA20).
Connectivity study of BA46 involvement in the executive control of language.
In addition to the left BA47 (Inferior frontal gyrus --Pars orbitalis) that has the highest intensity, the following regions appear "activated": BA46, BA6, BA 13, BA37, BA20, BA21, BA22, BA7 and BA18
Broca's complex" includes BA44, BA45, BA46, BA47, mesial BA6 (supplementary motor area; not seen) and extending subcortically toward the basal ganglia and the thalamus (not seen) (according to Ardila et al.
Should Broca's area include Brodmann area 47?/?Deberia el area de Broca incluir el area 47 de Brodmann?
Contemporary neuroimaging technique studies have supported the hypothesis regarding an active involvement of BA46 in linguistic processes (see Brodmann's Interactive Atlas), including verbal fluency (Abrahams et al.
It is noteworthy that the BA46 possesses extensive intracortical as well as fronto-subcortical connections (Cummings, 1983; Damasio & Anderson, 2003).
Considering the complex role of BA46 in language, a meta-analytic connectivity analysis utilizing MACM on the participation of BA46 in language was developed.
The meta-analysis was intended to assess the network of coactivations in which BA46 is involved.
The search conditions were: (1) studies reporting BA46 activation; (2) studies using fMRI ; (3) context: normal subjects; (4) activations: activation only; (5) handedness: right-handed subjects; (6) age 18-60 years; (7) domain: cognition, subtype: language; (8) Language: English.
Table 2 presents the main loci of brain connectivity of BA46 by Meta-analytic Connectivity Modeling (MACM).
Connectivity of BA46 involvement in the executive control of language/ Estudio de la conectividad del AB46 en el control ejecutivo del lenguaje
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