ARID1A

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ARID1A

A gene on chromosome 1p36.1-p35 that encodes AT-rich interactive domain-containing protein 1, which is highly expressed in the spleen, thymus, prostate, testes, ovaries, small intestine, colon and peripheral leukocytes. ARID1A is involved in transcriptional activation and repression of select genes by chromatin remodelling (by altering DNA-nucleosome topology). It is also involved in vitamin D-coupled transcription regulation by associating with the WINAC complex, a chromatin-remodelling complex recruited by vitamin D receptor.

ARID1A belongs to the neural progenitors-specific chromatin remodelling (npBAF) and the neuron-specific chromatin remodelling (nBAF) complexes, which are involved in switching developing neurons from stem/progenitors to post-mitotic chromatin remodelling as they exit the cell cycle and become committed to their adult state.

Molecular pathology
Defects in ARID1A cause mental retardation autosomal dominant type 14.
References in periodicals archive ?
Mississippi Gulf Coast 11975 Seaway Road, Suite B120,
With Vicat B120 softening temperatures as high as 190 C/374 F and glass-transition temperature (Tg) of up to 195 C/383 F, the CXT resins can withstand demanding assembly processes, such as cold reflow or wave soldering onto printed circuit boards.
With Vicat B120 softening temperatures as high as 190C and glass transition temperatures (Tg) of up to 195C, LEXAN CXT resins can provide converters with the potential to injection mold parts that can withstand demanding assembly processes, such as cold reflow or wave soldering onto printed circuit boards.
With Vicat B120 softening temperatures as high as 190AaAaAeAaC and glass transition temperatures (T of up to 195C, Lexan CXT resins can provide converters with the potential to injection mold parts that can withstand demanding assembly processes, such as cold reflow or wave soldering onto printed circuit boards.
With Vicat B120 softening temperatures as high as 190[degrees]C and glass transition temperatures (Tg) of up to 195C, Lexan CXT resins can provide converters with the potential to injection mold parts that can withstand demanding assembly processes, such as cold reflow or wave soldering onto printed circuit boards.
Study of Cu(II) biosorption by dried activated sludge: effect of physicochemical environment and kinetics study, Journal of Hazardous Materials B120: 193-200.
Evans letter to Editor Lomas, The Shaker 8 (January 1877), 7; Elder Giles Avery Journal, December 29, 1874, December 31, 1874, January L 1875, January 2, 1875, and January 9, 1875, WRHS V B120; Frederick W.
CIRCUS ACTS THERE will be stories and faces from the circus during an event which will be using non-toxic face paints at Small Heath Library, Muntz Street B120 9RX from 10.30am-noon on Monday.
Lexan 141 Property Unit Test resin Thermal [T.sub.9] [degrees]C DSC 150 HDT 0.45 MPa [degrees]C IS075/Bf 136 Vicat B120 [degrees]C IS0306 142 Rheological MVR ** cc/10min IS01133 12 Impact Notched Izod kJ/[m.sup.2] IS0180/1A 70 (23[degrees]C) Mechanical Tensile modulus GPa IS0527 2.3 Tensile stress at yield MPa IS0527 63 Tensile strain at yield % IS0527 6 Lexan Lexan XHT2141 XHT4141 Property BPI PC resin resin Thermal [T.sub.9] 185 165 185 HDT 0.45 MPa 173 155 173 Vicat B120 183 163 183 Rheological MVR ** 18.5 43 24 Impact Notched Izod 3 11 8 (23[degrees]C) Mechanical Tensile modulus 2.3 2.5 2.7 Tensile stress at yield 65 70 78 Tensile strain at yield 7 6.5 7 ** 300[degrees]C/2.16 kg load Table 2.
(15) Omitting the strictly testimonial evidence, the meagre surviving fragmentary instances of anti-occur only at B8.1, B67.2, and B120.3.