cyanocobalamin

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cyanocobalamin

 [si″ah-no-ko-bal´ah-min]
vitamin B12, a substance having hematopoietic activity found in liver, fish meal, eggs, and other natural sources, or produced from cultures of Streptomyces griseus; it combines with intrinsic factor for absorption and is needed for erythrocyte maturation. Absence of intrinsic factor leads to malabsorption of cyanocobalamin and results in pernicious anemia. Called also extrinsic factor. See also vitamin.
cyanocobalamin Co-57 a radiopharmaceutical used in the schilling test for the diagnosis of pernicious anemia.

cy·a·no·co·bal·a·min

(sī'an-ō-kō-bal'ă-min),
A complex of cyanide and cobalamin, as in vitamin B12, in which a cyanide group has filled the sixth coordinate position of the cobalt atom.

cyanocobalamin

(sī′ə-nō′kō-băl′ə-mĭn, sī-ăn′ō-)

vitamin B12

A water-soluble vitamin of animal origin required for DNA synthesis. It is a glycoprotein produced and secreted by the gastric parietal cells, and is absorbed from the GI tract bound to intrinsic factor; the body stores up to one years’ worth of vitamin B12 in the liver, kidneys and heart. Rapid cell turnover (e.g., growth spurts in children, malignancy) require increased amounts of vitamin B12. Vegans, who ingest no protein of animal origin, are at risk for vitamin B12 deficiency.

Increased by
Chronic myeloid leukaemia, chronic obstructive pulmonary disease, congestive heart failure, liver disease, obesity, polycythemia vera, renal failure.
 
Decreased by
Atrophic gastritis, drugs (antibiotics, anticonvulsants, antimalarials, antituberculous agents, chemotherapy, contraceptives, diuretics, oral hypoglycemics, sedatives), inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis), intrinsic factor deficiency (causing megaloblastic anaemia), malabsorption, malnutrition, parasites (e.g., Diphyllobotrium latum), veganism.

cyanocobalamin

Vitamin B12 A water soluble B vitamin, central to proper CNS function, and carbohydrate, protein and fat metabolism. See Vitamin B12.

cy·a·no·co·bal·a·min

(sī'ă-nō-kō-bal'ă-min)
A complex of cyanide and cobalamin, as in vitamin B12.

cyanocobalamin

Vitamin B12. This vitamin is necessary for the normal metabolism of carbohydrates, fats and proteins, for blood cell formation and for nerve function. It is used in the treatment of PERNICIOUS ANAEMIA and SPRUE. Brand names are Cytacon and Cytamen.

cyanocobalamin

see COBALAMIN.

cy·a·no·co·bal·a·min

(sī'ă-nō-kō-bal'ă-min)
A complex of cyanide and cobalamin, as in vitamin B12.

Patient discussion about cyanocobalamin

Q. Can a food rich in vitamin B12 will help for his depression or vitamin B12 pills are always required? Hi all…..having one question related to my friends depression and its relation to vitamin B12, as a medicine given to him by his Doctor. Can a food rich in vitamin B12 will help for his depression or vitamin B12 pills are always required?

A. Yes low level of vitamin B12 is associated with depression. You can complete its deficiency by having good diet which will cover the B12 requirements. What happens that depressed people tend to eat less of healthy food and which reduces the B12. So, it again reduces the capacity to fight against the depression.

More discussions about cyanocobalamin
References in periodicals archive ?
For pregnant women, a B12 deficiency can be extremely serious and could result in developing a birth defect known as neural tube defect.
However, the supplemental form of vitamin B12 is absorbed more quickly than B12 found in foods, so supplements are often advised if poor absorption is the cause of deficiency.
It is necessary to eat food of animal origin, such as meat, milk, and eggs, to take in vitamin B12, as it cannot be synthesized in the human body.
To confirm this, the scientists then made a type of vitamin B12 that emits fluorescent light when activated by a laser.
At present, our data revealed that powder-encapsulated rosemary has a promising effect to improve Vitamin B12 level 10% in diabetic patients and 29% in healthy persons.
Sample size was calculated to be 90 (45 in each group) estimated by using 5% level of significance and 90% power of test with expected percentage of B12 deficiency with GDM as 51.1% and without GDM as 21.9% (Sukumar et al., 2016).
Some studies have found that vitamin B12 deficiency is associated with obesity, whereas others have reported no association.9-11 Elevated body mass index (BMI) is associated with elevated systemic markers of inflammation including C-reactive protein (CRP) and peripheral leukocyte counts.12 There have been few clinical studies that have investigated paediatric obesity and inflammation using CRP and other inflammatory cytokines.13 It has been suggested that vitamin B12 levels are significantly lower in adult Turkish patients with metabolic syndrome (MS) than in those without MS.10 However, studies on the associations among vitamin B12 status, obesity severity, and MS in obese children and adolescents are rare.
SINTOMAS NEUROPSIQUIATRICOS ASOCIADOS AL DEFICIT DE VITAMINA B12
Vitamin B12 is extremely necessary before and after conception as studies have found women who do not consume proper amount have a higher risk of giving birth to a baby with a potential disability or a fatal birth defect.
Table 1 suggest that out oftotal 1110 patients, 9.5% (105/1110) had serum vitamin B12 < 100 pg/ml with mean MCV of 91.8 fl.
Vitamin B12 helps the body manufacture red blood cells and nerves; it also helps with DNA maintenance and other functions.