B) Inflamed filtration angle and sclera highlighting the predominant population of CD79a+ B-lymphocytes
. Original magnification x10.
produce immunoglobulins as a response to infection, cytokines as immunoregulatory cells, and as antigens they participate in T-B cooperation [2, 3].
Some stay there and develop into B-lymphocytes
, while others head to the thymus and become T-Iymphocytes.
This is an extremely uncommon finding, as the tropism of EBV for B-lymphocyte
has been associated with B-cells cancers, including Burkitt, Hodgkin, and diffuse large cell lymphomas [14,15]; conversely EBV-positive T-cell lymphoma is exceedingly uncommon in western populations and has been attributed either to a possible antiapoptotic action exerted by the viral DNA hosted in the infected T-cells and/or to signals transmitted by some viral proteins such as Latent Membrane Protein 1 causing the continuous stimulation of members of the TNF receptors [2,16].
When SAP is bound to the cytosolic SLAM, it is thought to enhance T- and B-lymphocyte
proliferation, CD8+ T cell activation by antigen-presenting B cells, T-lymphocyte cytokine secretion, and B-lymphocyte
antibody production [2, 3].
Among the inflammatory cells, there were less B-lymphocytes
(CD20 positive) than T-lymphocytes (CD5 positive).
Humoral immunity is dependent on a full repertoire of mature B-lymphocytes
capable of adequately mounting a primary and secondary immune response.
The IBDV actively replicates in B-lymphocytes
that found in medullary region of bursa of Fabricius (BF) which its target.
PRTX-100 binds to human B-lymphocytes
and macrophages and modulates immune processes pertaining to inflammation seen in autoimmune diseases.
Characteristics Control Low-count MBL Number of subjects 261 6 Medium age 30 69 Age range (years) 0-88 53-82 Gender Cord blood 19 -- Male 125 5 Female 117 1 Medium number of lymphocytes -- 1.466 Range (/[micro]L) -- 800-2100 % [CD5.sup.+] B-lymphocytes
-- 1.68 in total lymphocytes Range (%) -- 0.72-3.43 Characteristics High-count MBL CLL Number of subjects 12 21 Medium age 78 70 Age range (years) 57-97 58-81 Gender Cord blood -- -- Male 9 11 Female 3 10 Medium number of lymphocytes 3.933 41.714 Range (/[micro]L) 2.900-5.900 7.500-147.000 % [CD5.sup.+] B-lymphocytes
34.9 78.02 in total lymphocytes Range (%) 5.97-61.01 58.63-91.09 MBL: Monoclonal B-cell lymphocytosis; CLL: chronic lymphocytic leukemia.
Blood from patients and control individuals randomly selected from the individuals recruited at the Neurology Clinic was used for Epstein-Barr virus (EBV) transfection of B-lymphocytes
, EO patients (n = 10), LO patients (n = 10), and controls (n = 10).