B-endorphin

B-endorphin

a type of ENDORPHIN produced by the pituitary, which acts as a synaptic transmitter agent and neural hormone. It is produced, for example, after exercise, possibly resulting in ‘jogger's high’ sensations.
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In another study culture of Leydig cells with b-endorphin or naloxone manifested no significant changes of un-stimulated or hCG-stimulated testosterone secretion in 20 or 60 day old rats23.
Caffeine also results in increased B-endorphin concentrations, which may override the burning pain of intense activity.
* Circulating B-endorphin levels are increased in renal failure.
Yet another mechanism demonstrated that the elevations in LH were due to elevations in b-endorphin. (14), (15) This intercellular communicating agent is responsible for exerting inhibitory control on GnRH and on pituitary release.
It is believed to work by making the brain release b-endorphin, an opioid peptide, the driving force behind the pleasurable effects.
Local application of serotonin (5-HT) or fluoxetine in the nuclei accumbens and arcuato promotes local liberation of b-endorphin, demonstrating that the mechanism of action of SSRI and tricyclic antidepressants involves the serotoninergic modulation of the system of endogenous opioids (Zagen et al., 2002).
The activation of 5HT2 receptors in the Leydig cells by serotonin provokes a cascade of autocrine events that promote the intratesticular increase of corticotrophin releasing hormone (CRH) and b-endorphin (Dufau et al.).
Effects of Different Heavy-Resistance Exercise Protocols on Plasma B-Endorphin Concentrations.
Though several different types of endorphins have been isolated, the most potent and presumably most important is B-endorphin.
The hypothalamus-pituitary center releases b-endorphin into the circulation and CSF for a more distal analgesic effect.