BRAF

(redirected from B-Raf)

BRAF

A gene on chromsome 7q34 that encodes a protein of the raf/mil family of serine/threonine protein kinases, which plays a role in regulating the MAP kinase/ERKs-signalling pathway, affecting cell division, differentiation and secretion.

Molecular pathology
BRAF mutations are associated with cardiofaciocutaneous syndrome, which is characterised by heart defects, mental retardation and a distinctive facial appearance. Acquired BRAF mutations have been linked to non-Hodgkin lymphoma, colorectal cancer, melanoma, thyroid carcinoma, non-small cell lung carcinoma and adenocarcinoma of lung.
References in periodicals archive ?
XP-102 holds potential as an innovative therapy against B-RAF V600 mutated solid tumors including CRC and non-small cell lung cancer and hairy cell leukemia.
Jazz said Redx has the potential to work in RAF driven tumors where current selective B-RAF inhibitors and their respective combinations are ineffective due to acquired resistance mechanisms.
The pan-RAF inhibitor programme aims to overcome resistance mechanisms associated with clinically approved B-RAF selective drugs.
MapKure intends to develop BGB-3245, an investigational, oral, selective small molecule inhibitor of monomer and dimer forms of activating B-RAF mutations including V600 BRAF mutations, non-V600 B-RAF mutations, and RAF fusions.
In our laboratory, the AmpliSeq Cancer Hotspot panel v2 (Thermo Fischer Scientific, Waltham, Massachusetts) is used with the Ion Torrent Personal Genome Machine (Life Technologies, Grand Island, New York) to detect mutations in several hot spot regions in 50 oncogenes and tumor suppressor genes; currently, we only report mutations in EGFR, Kirsten rat sarcoma viral oncogene homolog (KRAS), and B-Raf proto oncogene (BRAF) on clinical samples (Figure 3).
This misreading of signals appears to occur because of a specific type of mutation in the protein B-Raf corrupts the timing of incoming growth signals, the researchers found, causing short pulses of Ras activation to reverberate for longer within an affected cell - similar to how the 'sustain' pedal on a piano causes individual notes to be drawn out and blur together.
[2] Human Genes: KRAS, KRAS proto-oncogene; NRAS, NRAS proto-oncogene; BRAF, B-Raf proto-oncogene; MLH1, mutLhomolog 1; PMS2, PMS1 homolog 2.
RAF kinases are of three types- A-RAF, B-RAF (BRAF), and C-RAF out of which BRAF is the most potent activator of the MAP kinase pathway.
The B-RAF gene, located on chromosome 7q34, encodes B-RAF serine-threonine kinase, which functions as an intracellular effector of the RAS/MAPK signaling cascade (Figure 1).
Roe et al., "Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF," Cell, vol.
He had a history of B-Raf proto-oncogene, serine/threonine kinase (BRAF)-positive metastatic melanoma with unknown primary and metastasis to the inguinal fossa and right thigh diagnosed two years previously.