BRAF

(redirected from B-Raf)

BRAF

A gene on chromsome 7q34 that encodes a protein of the raf/mil family of serine/threonine protein kinases, which plays a role in regulating the MAP kinase/ERKs-signalling pathway, affecting cell division, differentiation and secretion.

Molecular pathology
BRAF mutations are associated with cardiofaciocutaneous syndrome, which is characterised by heart defects, mental retardation and a distinctive facial appearance. Acquired BRAF mutations have been linked to non-Hodgkin lymphoma, colorectal cancer, melanoma, thyroid carcinoma, non-small cell lung carcinoma and adenocarcinoma of lung.
References in periodicals archive ?
RAF kinases are of three types- A-RAF, B-RAF (BRAF), and C-RAF out of which BRAF is the most potent activator of the MAP kinase pathway.
ASN003 is a novel and highly selective oral inhibitor of B-RAF and PI3 Kinase enzymes that is being evaluated in patients with advanced solid tumors with RAF or PI3K pathway alterations, e.
The list of oncologic biomarkers that can be used to identify patients who benefit from a particular therapy extends from some that have been established markers for a particular therapy for many years (such as the retinoic acid receptor translocation in acute promyelocytic leukemia) to those that have been discovered and targeted more recently such as epidermal growth factor receptor (EGFR) activating mutations in non-small cell lung cancer and serine/threonine-protein kinase B-raf (BRAF) mutations in melanoma (3).
He had a history of B-Raf proto-oncogene, serine/threonine kinase (BRAF)-positive metastatic melanoma with unknown primary and metastasis to the inguinal fossa and right thigh diagnosed two years previously.
Celator's pre-clinical data presented at the conference showed the broad applicability of the company's hydrophobic prodrug nanoparticle (HPN) delivery technology to MTAs from diverse classes, including inhibitors of MEK, Akt, HSP90, B-Raf and FGFR.
The decision is conditional upon the divestment of two of Novartis' cancer treatments: LGX818, a B-Raf inhibitor, and MEK162, a MEK inhibitor.
Melanovus' lead product candidate, Nanolipolee-007, is a liposomal formulation of a plant-derived compound that is a first-in-class cholesterol-transport inhibitor which has demonstrated anti-proliferative activity against certain melanoma cell lines (including B-raf resistant strains) in vitro as well as in early in vivo mouse studies.
Since February we have received positive Phase III data on three assets--our HIV integrase inhibitor, Albigutide for diabetes and our B-Raf inhibitor for treatment of melanoma.
Ademas, en esta cascada de senalizacion dirigida por K-RAS tambien esta involucrado B-RAF, esta es otra via para la activacion de las MAPK quinasas en el desarrollo del CCR.
Novel therapies that target the root causes of cancer (such as B-Raf, Bcr-Abl, EGFR and HER2), when given to the 'right' patients harboring those defects, clearly demonstrate substantial benefits compared with older chemo and radiation treatments--so much so, that biotech and pharma companies are now fully bought into this concept, even if it means smaller patient populations.
They analyzed human cancer cells, searching for ones that exhibit B-RAF mutations as well as elevated COT levels.
FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKC, B-Raf and S6K2.