It has also been found that, in the presence of cations, condensation of plasmid
B-DNA is enhanced by the insertion of d(CG)n sequence [54].
In Figure 3, the CD spectrum of free DNA has a positive peak at 279 nm and a negative peak at 247 nm which corresponds to
B-DNA form.
It is known that in a Bto-A transition, the
B-DNA marker band at 835 (phosphodiester mode) shifts toward a lower frequency at -800 [cm.sup.-1] and a new band appear at -870-860[cm.sup.1].
The circular dichroism spectra of severely affected AD DNA showed a typical left-handed Z-DNA conformation; whereas normal, young, and aged brain DNA have the usual
B-DNA conformation.
Gagna's discovery will help scientists understand how transitions in DNA structure regulate gene expression (
B-DNA to Z-DNA), and how DNA-protein, and DNA-drug interactions regulate genes.
Helix geometry and hydration in A-DNA,
B-DNA, and Z-DNA.
Use of axial Pattersons in assessment of compatibility of alternative
B-DNA structure with fibre X-ray data.
Z-DNA twists in the opposite direction from the typical, right-handed double helix, known as
B-DNA. The left-handed conformation requires quite a bit of extra energy to keep from reverting to a right-handed twist, notes Zhang.
Hydrogen peroxide and tumor necrosis factor-alpha induce NF-kappa
B-DNA binding in primary human T lymphocytes in addition to T cell lines.
Overstretching
B-DNA. The elastic response of individual double-stranded and single-stranded DNA molecules.
The right-handed form nestles into grooves of the right-handed helix of normal double-stranded DNA (called
B-DNA), but the left-handed from just doesn't fit.